53052-06-5

基本信息
惡唑并[4,5-B!吡啶-2(3H)硫酮
3H-惡唑并[4,5-B]吡啶-2-硫酮
[1,3]惡唑并[4,5-B]吡啶-2-硫醇
3H-[1,3]惡唑并[4,5-B]吡啶-2-硫酮
OXAZOLO[4,5-B]PYRIDINE-2-THIOL
OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE
[1,3]Oxazolo[4,5-b]pyridin-2-thiol
3H-OXAZOLO[4,5-B]PYRIDINE-2-THIONE
[1,3]OXAZOLO[4,5-B]PYRIDINE-2-THIOL
Oxazolo[4,5-b]pyridine-2(3H)-thione
1,3-Oxazolo[4,5-b]pyridin-2(3H)thione
Oxazolo[4,5-b]pyridin-2(3H)thione,99%
3H-[1,3]oxazolo[4,5-b]pyridine-2-thione
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表

16867-03-1

140-89-6

53052-06-5
步驟1:惡唑并[4,5-b]吡啶-2(3H)硫酮的合成 將2-氨基-3-羥基吡啶(5.0 g,45.45 mmol)和乙基黃原酸鉀(8.0 g,49.99 mmol)溶于吡啶(50 mL)中,于110℃下攪拌反應(yīng)過(guò)夜。反應(yīng)完成后,將混合物冷卻至0℃,加入冰水,并用濃鹽酸酸化。析出的固體經(jīng)過(guò)濾收集,真空干燥,得到目標(biāo)產(chǎn)物惡唑并[4,5-b]吡啶-2(3H)硫酮(6.0 g,產(chǎn)率86.95%)。 產(chǎn)物表征數(shù)據(jù): 1H NMR (DMSO-d6, 300 MHz): δ 8.24-8.22 (d, 1H), 7.90-7.87 (d, 1H), 7.30-7.26 (m, 1H)。 LCMS: m/z 153.0 [M + H]+。
參考文獻(xiàn):
[1] Patent: WO2015/104688, 2015, A1. Location in patent: Page/Page column 36
[2] Patent: US2016/340366, 2016, A1. Location in patent: Paragraph 0205; 0206
[3] Monatshefte fur Chemie, 2011, vol. 142, # 9, p. 895 - 899
[4] Journal of Organic Chemistry, 1995, vol. 60, # 17, p. 5721 - 5725
[5] European Journal of Medicinal Chemistry, 2005, vol. 40, # 1, p. 15 - 23