1109230-25-2

基本信息
5-Bromo-3,4-dihydroisoquinolin-1(2H)
5-BroMo-3,4-dihydroisoquinolin-1(2H)-one
5-bromo-3,4-dihydro-1(2H)-Isoquinolinone
5-Bromo-3,4-dihydro-2H-isoquinolin-1-one
1(2H)-Isoquinolinone, 5-bromo-3,4-dihydro-
5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one
物理化學(xué)性質(zhì)
制備方法

15115-60-3

1109230-25-2
以4-溴茚-1-酮為起始原料合成5-溴-3,4-二氫異喹啉-1(2H)-酮的一般步驟如下:在0℃下,將4-溴茚滿(mǎn)-1-酮(4.00g,18.9mmol)和甲磺酸(20.2mL,310mmol)溶于二氯甲烷(180mL)中,隨后緩慢加入疊氮化鈉(2.46g,37.9mmol)。反應(yīng)混合物逐漸升溫至室溫,并持續(xù)攪拌16小時(shí)。反應(yīng)完成后,將混合物倒入10%氫氧化鈉水溶液(200mL)中,用二氯甲烷(100mL)萃取。合并有機(jī)層,用無(wú)水硫酸鈉干燥,隨后減壓濃縮除去溶劑。粗產(chǎn)物通過(guò)乙酸乙酯(40mL)重結(jié)晶純化,得到目標(biāo)化合物5-溴-3,4-二氫異喹啉-1(2H)-酮(3.98g,17.6mmol,收率93%),為白色粉末。產(chǎn)物經(jīng)LCMS分析顯示純度為96%,保留時(shí)間(Rt)為1.225分鐘,電噴霧質(zhì)譜(ESMS)顯示m/z為226([M+H]+)。
參考文獻(xiàn):
[1] Patent: WO2014/153055, 2014, A2. Location in patent: Paragraph 0106-0107
[2] Patent: WO2015/20553, 2015, A1. Location in patent: Paragraph 00111-00112
[3] Patent: WO2015/50472, 2015, A1. Location in patent: Paragraph 00109; 00110
[4] Patent: WO2015/50471, 2015, A1. Location in patent: Paragraph 00105; 00106
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 9, p. 2670 - 2674
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2025/05/22 | XW02110923025204 | 5-溴-3,4-二氫異喹啉-1(2H)-酮 | 1109230-25-2 | 5G | 1567元 |
2025/05/22 | XW02110923025203 | 5-溴-3,4-二氫異喹啉-1(2H)-酮 | 1109230-25-2 | 1G | 399元 |
2025/05/22 | XW02110923025202 | 5-溴-3,4-二氫異喹啉-1(2H)-酮 | 1109230-25-2 | 250MG | 191元 |