
2-Methoxy-3-(trifluoromethyl)pyridine synthesis
- Product Name:2-Methoxy-3-(trifluoromethyl)pyridine
- CAS Number:121643-44-5
- Molecular formula:C7H6F3NO
- Molecular Weight:177.12

124-41-4
727 suppliers
$12.00/25g

65753-47-1
379 suppliers
$8.00/5g

121643-44-5
225 suppliers
$5.00/1g
Yield:121643-44-5 89%
Reaction Conditions:
in methanol at 20; for 48 h;
Steps:
2-methoxy-3-trifluoromethylpyridine
2-Chloro-3-trifluoromethyl-pyridine (3 g, 16.53 mmol) was dissolved in 30ml of a solution of sodium methoxide (5.4M) in methanol. The mixture was stirred at ambient temperature for 2 days. After this period of time, the reaction was taken into ice and extracted with DCM three times. The combined extract was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give 2-methoxy-3-trifluoromethyl-pyridine as a light liquid (2.7 g, 89% yield). 1 H-NMR (400 MHz, DMSO-d6, 298 K): ? ppm 3.98 (s, 3H) 7.2 (dd, 1 H) 8.1 1 (d, 1 1-1) 8.45 (d, 1 H). MS: 178.1 [M+1 ]+, Rt(1) =1 .29 min.
References:
WO2013/57711,2013,A1 Location in patent:Page/Page column 45-46

81290-20-2
419 suppliers
$13.00/1g

112197-15-6
190 suppliers
$9.00/1g

121643-44-5
225 suppliers
$5.00/1g

1628-89-3
339 suppliers
$17.96/25g

2926-30-9
290 suppliers
$11.00/5g

121643-44-5
225 suppliers
$5.00/1g

2926-29-6
308 suppliers
$6.00/5g

163105-90-6
260 suppliers
$5.00/250mg

121643-44-5
225 suppliers
$5.00/1g

67-56-1
782 suppliers
$9.00/25ml

124-41-4
727 suppliers
$12.00/25g

65753-47-1
379 suppliers
$8.00/5g

121643-44-5
225 suppliers
$5.00/1g