手性磷酸是重要的手性Brønsted酸不對稱合成催化劑。其具有較強(qiáng)酸性，是雙功能催化劑，能通過微調(diào)結(jié)構(gòu)控制反應(yīng)立體選擇性。它可高效催化多種不對稱反應(yīng)^[1-6]，如Friedel–Crafts反應(yīng)、Mannich反應(yīng)、不對稱氫轉(zhuǎn)移反應(yīng)、環(huán)加成反應(yīng)等，在立體構(gòu)型上有很好的選擇性。手性磷酸的發(fā)展為手性化合物合成提供了有力手段，推動了藥物研發(fā)等領(lǐng)域的發(fā)展。

為助力相關(guān)研究，本次特別推出包含5種優(yōu)勢催化劑結(jié)構(gòu)的手性磷酸試劑盒，這些催化劑在一些反應(yīng)中均已表現(xiàn)出優(yōu)異的催化活性與選擇性。以下為其部分應(yīng)用實(shí)例：

手性磷酸（CAS: 791616-63-2）作為催化劑，以2-芳基吲哚啉為可回收氫供體，可高效實(shí)現(xiàn)酮亞胺不對稱轉(zhuǎn)移氫化反應(yīng)^[7]；以2-氘代苯并噻唑啉為氘供體，可實(shí)現(xiàn)酮亞胺和α-亞胺酯的不對稱轉(zhuǎn)移氘代反應(yīng)^[8]。

手性磷酸（CAS: 791616-62-1）可催化的烯酮二硫縮醛不對稱質(zhì)子化反應(yīng)，實(shí)現(xiàn)外消旋α-芳基氫化香豆素衍生物的去消旋化^[9]。

手性磷酸（CAS: 699006-54-7）可用于α-取代丙烯醛與1,2-二氫吡啶的高對映選擇性Diels-Alder反應(yīng)，生成具有高對映選擇性的異奎寧環(huán)^[10]。

手性磷酸試劑盒

參考文獻(xiàn)

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