
Vismodegib Impurity 5 NEW
Price | Get Latest Price | ||
Package | 10mg | 50mg | 100mg |
Min. Order: | 10mg |
Supply Ability: | 1000 |
Update Time: | 2025-07-31 |
Product Details
Product Name: Vismodegib Impurity 5 | CAS No.: 916050-62-9 |
Min. Order: 10mg | Purity: 99%+ HPLC |
Supply Ability: 1000 | Release date: 2025/07/31 |
Molecular formula: C11H7ClN2O2 |
Vismodegib Impurity 5;916050-62-9
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com.
Product Information
Product Number: V043005
English Name: Vismodegib Impurity 5
English Alias: 2-(4-chloro-3-nitrophenyl)pyridine
CAS Number: 916050-62-9
Molecular Formula: C??H?ClN?O?
Molecular Weight: 234.64
Advantages
Well-defined and highly characteristic structure: A simple aromatic structure containing chlorine atom, nitro group, and pyridine ring, which is significantly different from the benzamide and methylsulfonyl structures of Vismodegib. It can be quickly identified by techniques like HPLC and GC-MS, providing a specific marker for impurity detection;
High stability and traceability: The aromatic nitro structure is stable under conventional storage conditions. As a potential intermediate impurity in Vismodegib synthesis (the nitro group may be subsequently reduced to amino group for amidation), it can directly reflect residual nitro compounds in raw materials or incomplete reduction reactions, improving the accuracy of process tracing;
High detection sensitivity: The strong electron-withdrawing property of the nitro group results in significant response in UV detection, enabling trace analysis via HPLC-UV, reducing detection costs and enhancing method applicability.
Applications
Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Impurity 5 in Vismodegib APIs, ensuring residual nitro intermediates in raw materials meet quality standards;
Synthesis process optimization: Reducing residual unreduced intermediates by monitoring the impurity content and optimizing the catalyst (e.g., palladium on carbon) and reaction time of nitro reduction;
Stability studies: Investigating the degradation behavior of this impurity under light and high temperature (e.g., nitro reduction or oxidation) to assess its potential impact on the stability of Vismodegib formulations.
Background Description
Research Status
Detection method optimization: Using HPLC-DAD with optimized separation conditions based on the characteristic UV absorption of nitro groups (around 254nm) to achieve trace detection (detection limits up to ppm level);
Reduction process improvement: Enhancing nitro reduction efficiency by adjusting hydrogenation pressure and temperature to reduce impurity formation;
Toxicological evaluation: Assessing the potential mutagenicity of this nitro compound via Ames test to support rational impurity limit setting;
Raw material control strategies: Establishing limit standards for the impurity in raw materials to minimize its introduction into the Vismodegib synthesis system
Product Information
Product Number: V043005
English Name: Vismodegib Impurity 5
English Alias: 2-(4-chloro-3-nitrophenyl)pyridine
CAS Number: 916050-62-9
Molecular Formula: C??H?ClN?O?
Molecular Weight: 234.64
Advantages
Well-defined and highly characteristic structure: A simple aromatic structure containing chlorine atom, nitro group, and pyridine ring, which is significantly different from the benzamide and methylsulfonyl structures of Vismodegib. It can be quickly identified by techniques like HPLC and GC-MS, providing a specific marker for impurity detection;
High stability and traceability: The aromatic nitro structure is stable under conventional storage conditions. As a potential intermediate impurity in Vismodegib synthesis (the nitro group may be subsequently reduced to amino group for amidation), it can directly reflect residual nitro compounds in raw materials or incomplete reduction reactions, improving the accuracy of process tracing;
High detection sensitivity: The strong electron-withdrawing property of the nitro group results in significant response in UV detection, enabling trace analysis via HPLC-UV, reducing detection costs and enhancing method applicability.
Applications
Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Impurity 5 in Vismodegib APIs, ensuring residual nitro intermediates in raw materials meet quality standards;
Synthesis process optimization: Reducing residual unreduced intermediates by monitoring the impurity content and optimizing the catalyst (e.g., palladium on carbon) and reaction time of nitro reduction;
Stability studies: Investigating the degradation behavior of this impurity under light and high temperature (e.g., nitro reduction or oxidation) to assess its potential impact on the stability of Vismodegib formulations.
Background Description
Research Status
Detection method optimization: Using HPLC-DAD with optimized separation conditions based on the characteristic UV absorption of nitro groups (around 254nm) to achieve trace detection (detection limits up to ppm level);
Reduction process improvement: Enhancing nitro reduction efficiency by adjusting hydrogenation pressure and temperature to reduce impurity formation;
Toxicological evaluation: Assessing the potential mutagenicity of this nitro compound via Ames test to support rational impurity limit setting;
Raw material control strategies: Establishing limit standards for the impurity in raw materials to minimize its introduction into the Vismodegib synthesis system
Applications
This product is intended for laboratory use only!
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
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