午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Vismodegib Impurity 5
Vismodegib Impurity 5
  • Vismodegib Impurity 5
  • Vismodegib Impurity 5
  • Vismodegib Impurity 5
  • Vismodegib Impurity 5
  • Vismodegib Impurity 5

Vismodegib Impurity 5 NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-31

Product Details

Product Name: Vismodegib Impurity 5 CAS No.: 916050-62-9
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/31
Molecular formula: C11H7ClN2O2

Vismodegib Impurity 5;916050-62-9

Article illustration

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
.


  • Product Information

  • Product Number: V043005

  • English Name: Vismodegib Impurity 5

  • English Alias: 2-(4-chloro-3-nitrophenyl)pyridine

  • CAS Number: 916050-62-9

  • Molecular Formula: C??H?ClN?O?

  • Molecular Weight: 234.64

  • Advantages

  • As a nitro-containing impurity of Vismodegib, this compound has the following advantages:

  • Well-defined and highly characteristic structure: A simple aromatic structure containing chlorine atom, nitro group, and pyridine ring, which is significantly different from the benzamide and methylsulfonyl structures of Vismodegib. It can be quickly identified by techniques like HPLC and GC-MS, providing a specific marker for impurity detection;

  • High stability and traceability: The aromatic nitro structure is stable under conventional storage conditions. As a potential intermediate impurity in Vismodegib synthesis (the nitro group may be subsequently reduced to amino group for amidation), it can directly reflect residual nitro compounds in raw materials or incomplete reduction reactions, improving the accuracy of process tracing;

  • High detection sensitivity: The strong electron-withdrawing property of the nitro group results in significant response in UV detection, enabling trace analysis via HPLC-UV, reducing detection costs and enhancing method applicability.

  • Applications

  • Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Impurity 5 in Vismodegib APIs, ensuring residual nitro intermediates in raw materials meet quality standards;

  • Synthesis process optimization: Reducing residual unreduced intermediates by monitoring the impurity content and optimizing the catalyst (e.g., palladium on carbon) and reaction time of nitro reduction;

  • Stability studies: Investigating the degradation behavior of this impurity under light and high temperature (e.g., nitro reduction or oxidation) to assess its potential impact on the stability of Vismodegib formulations.

  • Background Description

  • Vismodegib is a Hedgehog signaling pathway inhibitor used in the treatment of tumors such as basal cell carcinoma. Its synthesis may involve nitro-containing aromatic intermediates (e.g., 2-(4-chloro-3-nitrophenyl)pyridine). Incomplete nitro reduction or inadequate raw material purification can lead to residual impurities. Such nitro impurities may have potential toxicity (e.g., mutagenicity), making their control a key part of ensuring Vismodegib quality and safety.
  • Research Status

  • Current research focuses on:

  • Detection method optimization: Using HPLC-DAD with optimized separation conditions based on the characteristic UV absorption of nitro groups (around 254nm) to achieve trace detection (detection limits up to ppm level);

  • Reduction process improvement: Enhancing nitro reduction efficiency by adjusting hydrogenation pressure and temperature to reduce impurity formation;

  • Toxicological evaluation: Assessing the potential mutagenicity of this nitro compound via Ames test to support rational impurity limit setting;

  • Raw material control strategies: Establishing limit standards for the impurity in raw materials to minimize its introduction into the Vismodegib synthesis system

Applications


This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com








Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$38.00/5mg
VIP5Y
TargetMol Chemicals Inc.
2025-07-15
$0.00/25kg
VIP1Y
Shaanxi Dideu New Materials Co. Ltd
2025-03-15
$0.00/1g
VIP2Y
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2024-07-24
INQUIRY