
Vismodegib Impurity 10 NEW
Price | Get Latest Price | ||
Package | 10mg | 50mg | 100mg |
Min. Order: | 10mg |
Supply Ability: | 1000 |
Update Time: | 2025-07-17 |
Product Details
Product Name: Vismodegib Impurity 10 | CAS No.: 1977536-53-0 |
Min. Order: 10mg | Purity: 99%+ HPLC |
Supply Ability: 1000 | Release date: 2025/07/17 |
Molecular formula: C22H14Cl2N4 |
Vismodegib Impurity 10;1977536-53-0
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com.
Product Information
Product Number: V043010
English Name: Vismodegib Impurity 10
English Alias: 1,2-bis(4-chloro-3-(pyridin-2-yl)phenyl)diazene
CAS Number: 1977536-53-0
Molecular Formula: C??H??Cl?N?
Molecular Weight: 405.28
Advantages
Well-defined and highly characteristic structure: A symmetric structure with two chloropyridylphenyl groups linked by an azo bond (-N=N-), significantly different from the benzamide monomolecular structure of Vismodegib. It can be accurately identified by techniques like HPLC and LC-MS, providing a specific marker for impurity detection;
High stability and traceability: The azo bond is relatively stable under dark conditions. As a product of oxidative coupling of aniline raw materials in Vismodegib synthesis, it directly reflects the degree of amino oxidation, improving the traceability accuracy of oxidation control in the process;
High detection sensitivity: The azo bond forms a large conjugated system with two aromatic rings, showing characteristic absorption in the visible region (400-500nm). Trace analysis can be achieved via HPLC-UV/Vis, reducing detection difficulty and enhancing method specificity.
Applications
Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Impurity 10 in Vismodegib APIs, ensuring residual oxidative coupling products of aniline raw materials meet quality standards;
Synthesis process optimization: Reducing azo impurity formation by monitoring its content and optimizing antioxidant measures (e.g., adding antioxidants) and inert gas protection conditions in the reaction system;
Stability evaluation: Used to assess the oxidative degradation trend of Vismodegib formulations during storage, assisting in verifying the light protection and sealing performance of packaging materials.
Background Description
Research Status
Detection method optimization: Using UPLC-DAD to optimize detection wavelengths based on the characteristic visible absorption of azo bonds, achieving trace detection of this impurity (detection limits up to ppm level);
Oxidation inhibition strategies: Adding trace hindered phenol antioxidants (e.g., BHT) to the synthesis system to inhibit oxidative coupling of aniline raw materials and reduce impurity formation;
Toxicological evaluation: Assessing the potential sensitization of this azo compound through skin sensitization tests to support strict impurity limit standards;
Storage condition studies: Exploring the impact of temperature, light, and oxygen concentration on the formation rate of this impurity to establish optimal storage protocols for Vismodegib APIs
Product Information
Product Number: V043010
English Name: Vismodegib Impurity 10
English Alias: 1,2-bis(4-chloro-3-(pyridin-2-yl)phenyl)diazene
CAS Number: 1977536-53-0
Molecular Formula: C??H??Cl?N?
Molecular Weight: 405.28
Advantages
Well-defined and highly characteristic structure: A symmetric structure with two chloropyridylphenyl groups linked by an azo bond (-N=N-), significantly different from the benzamide monomolecular structure of Vismodegib. It can be accurately identified by techniques like HPLC and LC-MS, providing a specific marker for impurity detection;
High stability and traceability: The azo bond is relatively stable under dark conditions. As a product of oxidative coupling of aniline raw materials in Vismodegib synthesis, it directly reflects the degree of amino oxidation, improving the traceability accuracy of oxidation control in the process;
High detection sensitivity: The azo bond forms a large conjugated system with two aromatic rings, showing characteristic absorption in the visible region (400-500nm). Trace analysis can be achieved via HPLC-UV/Vis, reducing detection difficulty and enhancing method specificity.
Applications
Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Impurity 10 in Vismodegib APIs, ensuring residual oxidative coupling products of aniline raw materials meet quality standards;
Synthesis process optimization: Reducing azo impurity formation by monitoring its content and optimizing antioxidant measures (e.g., adding antioxidants) and inert gas protection conditions in the reaction system;
Stability evaluation: Used to assess the oxidative degradation trend of Vismodegib formulations during storage, assisting in verifying the light protection and sealing performance of packaging materials.
Background Description
Research Status
Detection method optimization: Using UPLC-DAD to optimize detection wavelengths based on the characteristic visible absorption of azo bonds, achieving trace detection of this impurity (detection limits up to ppm level);
Oxidation inhibition strategies: Adding trace hindered phenol antioxidants (e.g., BHT) to the synthesis system to inhibit oxidative coupling of aniline raw materials and reduce impurity formation;
Toxicological evaluation: Assessing the potential sensitization of this azo compound through skin sensitization tests to support strict impurity limit standards;
Storage condition studies: Exploring the impact of temperature, light, and oxygen concentration on the formation rate of this impurity to establish optimal storage protocols for Vismodegib APIs
This product is intended for laboratory use only!
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
Company Profile Introduction
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