Tenofovir disoproxil fumarate
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- CAS-Nr.
- 202138-50-9
- Englisch Name:
- Tenofovir disoproxil fumarate
- Synonyma:
- CS-137;Tenofovir Disproxil FuMarate;2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate;CS-112;GS-433105;GS4331-05;Aids031697;GS 4331-05;GS-4331-05;Aids-031697
- CBNumber:
- CB7946998
- Summenformel:
- C23H34N5O14P
- Molgewicht:
- 635.52
- MOL-Datei:
- 202138-50-9.mol
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Tenofovir disoproxil fumarate Eigenschaften
- Schmelzpunkt:
- 113-115°C
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Wasserl?slichkeit
- H2O: 3mg/mL, clear (warmed)
- InChIKey
- VCMJCVGFSROFHV-PSMOUDLHNA-N
- SMILES
- C(/C(=O)O)=C\C(=O)O.C(N1C=NC2C(=NC=NC1=2)N)[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C |&1:19,r|
- CAS Datenbank
- 202138-50-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
| H412 |
Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tenofovir disoproxil fumarate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir . Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.
Chemische Eigenschaften
White Solid
Verwenden
Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Definition
ChEBI: A fumarate salt prepared from equimolar amounts of tenofovir disoproxil and fumaric acid. It is used in combination therapy for the treatment of HIV infection.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Tenofovir disoproxil fumarate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tenofovir disoproxil fumarate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 599)Lieferanten
202138-50-9()Verwandte Suche:
- 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-
- Aids031697
- Aids-031697
- Bis(neopentyloc)pmpa
- Tenofovir diisoproxil fuMarate
- Tenofovir dipivoxil FuMarate(TDF)
- Tenofovir Disoproxil Fumarate (200 mg)
- Tenofovir DF
- Disoproxil fumarate
- (((((1-(6-aMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) diisopropyl dicarbonate fuMarate
- enofovir disoproxil fuMarate
- Tenofovir Disoproxil FuMarate I
- FuMaric acid tenofovir ester
- 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, 1,9-bis(1-methylethyl) ester, 5-oxide, (2E)-2-butenedioate (1:1)
- GS-1278 Disoproxil Fumarate
- Tenofovir disoproxil fumarate
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate
- Tenofovir Disoproxil Dumarate
- Tenofovir disoproxil fumarate, >=98%
- Tenofovir Disoproxil Fumarate (TDF)
- (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) di
- Tenofovir disoproxil fumarate
- TENOFOVIR DISOPROXIC
- 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate
- Tenofovir disoproxil Impurity 11
- TENOFOVIR DISOPROXIL FUMARATE 98%
- CS-112
- Tenofovir dipivoxil Fumarate
- (R)-(((((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) diisopropyl bis(carbonate), fumaric acid
- Tenofovir disoproxil fumarate USP/EP/BP
- 202138-50-9Tenofovir disoproxil fumarate
- Tenofovir Disoproxil Fumarate (USFDA)
- 5-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]-2,4,6,8-tetraoxa-5-phosphanonanedioic Acid 1,9-Bis(1-methylethyl) Ester 5-Oxide (2E)-2-Butenedioate
- Tenofovir Disoproxil Fumarate (Tenofovir DF)
- Tenofovir disoproxil D12 fumarate
- Tenofovir Disoproxil fumarateQ: What is
Tenofovir Disoproxil fumarate Q: What is the CAS Number of
Tenofovir Disoproxil fumarate Q: What is the storage condition of
Tenofovir Disoproxil fumarate Q: What are the applications of
Tenofovir Disoproxil fumarate
- Tenofovir Disoproxil Fumarate (1643656)
- 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate
- Tenofovir Disproxil FuMarate
- CS-137
- Tenofovir? Disoroxil Fumarate
- 1,3-Benzodioxole-5-carboxaldehyde,12-methoxy-
- CAS 202138-50-9 Tenofovir disoproxil fumarate
- Tenofovir Impurity 115 Fumarate
- (1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(isopropoxycarbonyloxymethoxy)phosphoryl]oxymethyl isopropyl carbonate
- Tenofovir Disoproxil Fumarate CRS
- GS 4331-05
- GS-433105
- GS-4331-05
- GS4331-05
- Tenofovir Impurity 138 Fumarate
- bis{[(isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate (1:1)
- Tenofovir Disoproxil Fumarate, 10 mM in DMSO
- TENOFOVIR DISOPROXIL FUMARATE (NON-STERILE DRUG SUBSTANCE)
- TENOFOVIR DISOPROXIL FUMARATE [DRUG SUBSTANCE(NON-STERILE)]
- Tenofovir disoproxil fumarate - Bio-X ?
- Tenofovir disoproxil fumarate RS
- 202138-50-9
- 14727-20-6
