93000-03-4

基本信息
N-BOC-DL-蛋氨酸
(叔丁氧基羰基)甲硫氨酸
N-叔丁氧羰基-DL-蛋氨酸
BOC-DL-蛋氨酸, ≥98%
2-BOC-氨基-4-甲基磺胺-奶油酸
N-[(1,1-二甲基乙氧基)羰基]-蛋氨酸
2-(叔丁氧基羰基氨基)-4-(甲基硫代)丁酸
2-((叔丁氧羰基)氨基)-4-(甲硫基)丁酸
BOC-DL-MET-OH
BOC-DL-METHIONINE
N-Boc-DL-methionine
Boc-DL-methionine99%
BOC-DL-MET-OH USP/EP/BP
N-Boc-DL-Methionine, ≥98%
(tert-Butoxycarbonyl)methionine
N-T-BUTOXYCARBONYL-DL-METHIONINE
N-tert-Butoxycarbonyl-DL-methionine
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表

24424-99-5

59-51-8

93000-03-4
以二碳酸二叔丁酯和DL-蛋氨酸為原料合成2-((叔丁氧羰基)氨基)-4-(甲硫基)丁酸的一般步驟:將DL-蛋氨酸(20 g,0.134 mol)溶于250 mL 10%碳酸鈉水溶液中,冷卻至0℃。在1小時(shí)內(nèi)緩慢滴加二碳酸二叔丁酯(32.17 g,0.147 mol)溶于100 mL二惡烷的溶液。滴加完畢后,移除冷卻浴,將反應(yīng)混合物在室溫下攪拌過(guò)夜。反應(yīng)完成后,減壓蒸發(fā)除去約一半的溶劑。用冰浴冷卻反應(yīng)混合物,并用10%檸檬酸水溶液調(diào)節(jié)pH至2-3。用乙酸乙酯(3×200 mL)萃取水相,合并有機(jī)層,依次用200 mL水和200 mL飽和食鹽水(2×200 mL)洗滌。有機(jī)層用無(wú)水硫酸鈉干燥,過(guò)濾后減壓濃縮。殘余物在-20℃下用乙酸乙酯-石油醚混合溶劑研磨,得到純產(chǎn)物2-((叔丁氧羰基)氨基)-4-(甲硫基)丁酸(28 g,收率84%)。產(chǎn)物為白色固體,熔點(diǎn)88-90℃(文獻(xiàn)值87-91℃)。薄層色譜(TLC)Rf = 0.67(展開(kāi)劑S4)。1H NMR(600 MHz,CDCl3)δ:5.27(br s,1H,NH),4.45(m,1H),2.58(t,J = 7.5 Hz,2H),2.18(m,1H),2.11(s,3H,SCH3),1.98(m,1H),1.45(s,9H,t-Bu)。13C NMR(150.9 MHz,CDCl3)δ:176.91(COOH),155.60(NCOO),80.32,52.73,31.86,29.93,28.24(3C),15.32。IR(KBr)νmax(cm-1):3380(NH),3500-2800(br,COOH),1715(C=O,酸),1673(C=O,氨基甲酸酯),1543(酰胺II),2977(s),1368(m,CH3)。高分辨質(zhì)譜(HRMS-ESI)計(jì)算值C10H19O4NNaS [M+Na]+:272.09270,實(shí)測(cè)值:272.09281。
參考文獻(xiàn):
[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 1, p. 350 - 359
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 256 - 275
[3] Journal of Organic Chemistry, 2007, vol. 72, # 21, p. 8046 - 8053
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008, vol. 47, # 1, p. 97 - 105
[5] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 6, p. 1551 - 1554
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2025/05/22 | H66372 | N-Boc-DL-甲硫氨酸, 98% N-Boc-DL-methionine, 98% | 93000-03-4 | 1g | 548元 |
2025/05/22 | H66372 | N-Boc-DL-甲硫氨酸, 98% N-Boc-DL-methionine, 98% | 93000-03-4 | 5g | 1308元 |
2025/05/22 | HY-W052309 | BOC-DL-蛋氨酸 (tert-Butoxycarbonyl)methionine | 93000-03-4 | 25 g | 226元 |