5241-66-7
5241-66-7 結(jié)構(gòu)式
基本信息
N-叔丁氧羰基-D-蛋氨酸
Boc-D-Met-OH
N-BOC-D-蛋氨酸, 98+%
BOC-D-METHIONINE
BOC-D-MET-OH
N-ALPHA-T-BOC-D-METHIONINE
N-ALPHA-T-BUTYLOXYCARBONYL-D-METHIONINE
N-ALPHA-TERT-BUTYLOXYCARBONYL-D-METHIONINE
N-BOC-D-METHIONINE
N-(TERT-BUTOXYCARBONYL)-D-METHIONIN
N-(TERT-BUTOXYCARBONYL)-D-METHIONINE
T-BUTYLOXYCARBONYL-D-METHIONINE
Boc-D-Met-OH
n-box-d-methionine
N-Boc-D-methionine, 98+%
(2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid
D-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-
N-(tert-butyloxycarbonyl)-D-methionine
N-[(1,1-Dimethylethoxy)carbonyl]-D-methionine
物理化學(xué)性質(zhì)
制備方法
348-67-4
24424-99-5
5241-66-7
(a) 叔丁氧基羰基-D-甲硫氨酸的制備：將D-甲硫氨酸（50.3 g，0.34 mol）溶解于含有碳酸鈉（71.5 g，0.675 mol）的水溶液（700 mL）中。向該溶液中緩慢加入二碳酸二叔丁酯（81.0 g，0.37 mol）的二惡烷（250 mL）溶液，反應(yīng)混合物于室溫下攪拌反應(yīng)16小時(shí)。反應(yīng)完成后，加入水（1.5 L）稀釋，并用乙醚（2 × 500 mL）洗滌兩次以去除未反應(yīng)的原料。隨后，通過加入固體檸檬酸將水相酸化至pH 3，并用乙酸乙酯（3 × 500 mL）萃取產(chǎn)物。合并有機(jī)相，依次用水（2 × 500 mL）和飽和鹽水（500 mL）洗滌，最后用無水硫酸鎂干燥。減壓蒸發(fā)溶劑，得到叔丁氧基羰基-D-甲硫氨酸，為無色油狀物（87.6 g，收率100%）。產(chǎn)物的比旋光度為[α]D +19.0°（c = 1%，甲醇）。
參考文獻(xiàn)：
[1] Patent: US4863953, 1989, A
[2] Journal of the Chemical Society - Series Chemical Communications, 1989, # 22, p. 1740 - 1742
[3] Journal of Organic Chemistry, 1999, vol. 64, # 14, p. 5166 - 5175
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4815 - 4830