6972-27-6
6972-27-6 結(jié)構(gòu)式
基本信息
1,3-二甲基-6-氯尿嘧啶
6-氯-1,3-二甲基尿嘧啶
6-CHLORO-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE
6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
6-CHLORO-1,3-DIMETHYLURACIL
AURORA KA-4432
1,3-Dimethyl-4-chlorouracil
2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dimethyl-
4-Chloro-1,3-dimethyluracil
6-Chloro-1,3-dimethyl
6-CHLORO-1,3-DIMETHYLURACIL 99%
6-CHLORO-1,3-DIMETHYLPYRIMIDINE-2,6-1H,3H-DIONE
6-Chloro-1,3-dimethylpyrimidine-2,4-dione
1,3-Dimethyl-6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
769-42-6
6972-27-6
以1,3-二甲基巴比妥酸（化合物SM1）（7 kg，44.9 mmol）為原料，將其溶于120 kg磷酰氯（POCl3）中。緩慢滴加水（2.2 kg，122 mol）至上述溶液中。滴加完畢后，緩慢加熱至回流，維持反應(yīng)6小時；反應(yīng)進程通過高效液相色譜（HPLC）監(jiān)測。反應(yīng)完成后，將反應(yīng)液緩慢倒入大量冰水（100 L）中，隨后用二氯甲烷（50 L）萃取兩次，合并有機相。有機相用飽和鹽水（20 L）洗滌，無水硫酸鈉干燥，過濾后濃縮有機相，最后通過真空干燥得到黃色固體產(chǎn)物6-氯-1,3-二甲基尿嘧啶（化合物SM2）（7.2 kg），收率為92.3%。
參考文獻：
[1] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987, vol. 23, # 6, p. 690 - 697
[2] Khimiya Geterotsiklicheskikh Soedinenii, 1987, vol. 23, # 6, p. 836 - 844
[3] Patent: CN103755705, 2017, B. Location in patent: Paragraph 0033; 0034; 0035
[4] Justus Liebigs Annalen der Chemie, 1958, vol. 612, p. 158,162
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995, vol. 34, # 10, p. 869 - 871