3160-47-2
3160-47-2 結(jié)構(gòu)式
基本信息
CBZ-L-ASPARTIC ACID 4-METHYL ESTER
N-ALPHA-CARBOBENZOXY-L-ASPARATIC ACID BETA-METHYL ESTER
N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 4-METHYL ESTER
N-CBZ-L-ASPARTIC ACID BETA-METHYL ESTER
(S)-2-BENZYLOXYCARBONYLAMINO-SUCCINIC ACID 4-METHYL ESTER
(S)-2-N-CBZ-AMINO-SUCCINIC ACID 4-METHYL ESTER
Z-ASPARTIC ACID(OME)-OH
Z-ASP(OME)-OH
Z-L-ASPARTIC ACID 4-METHYL ESTER
Z-L-ASPARTIC ACID BETA-METHYL ESTER
N-cbz-L-aspartic acid B-methyl ester
CBZ-L-ASPARTIC ACID BETA METHYL ESTER
Z-L-ASPARTIC ACID B-METHYLESTER
N-carbobenzyloxy-L-aspartic acid beta-methyl ester
N-Cbz-L-aspartic acid β-methyl ester, Z-L-Aspartic acid 4-methyl ester
物理化學(xué)性質(zhì)
制備方法
2177-62-0
501-53-1
3160-47-2
將30.5 g (207 mmol) (S)-2-氨基-4-甲氧基-4-氧代丁酸溶解于726 mL蒸餾水中，加入260 mL乙醚。隨后，加入40.15 g (290 mmol)碳酸鉀并攪拌至完全溶解，再緩慢加入41.5 mL (290 mmol)氯甲酸芐酯。反應(yīng)混合物在室溫下持續(xù)攪拌4小時(shí)。反應(yīng)完成后，進(jìn)行相分離，棄去有機(jī)層。水層用乙醚洗滌數(shù)次，隨后用1N鹽酸調(diào)節(jié)pH至1。水層再次用乙醚進(jìn)行多次萃取，合并有機(jī)層并用硫酸鎂干燥。最后，通過真空濃縮得到55 g (2S)-4-甲氧基-4-氧代-2-(苯基甲氧基羰基氨基)丁酸，收率為94%。產(chǎn)物經(jīng)1H NMR (300 MHz, CDCl3)表征：δ 8.23 (s, 1H), 7.35 (m, 5H), 5.87 (d, 1H), 5.12 (s, 2H), 4.69 (m, 1H), 3.68 (s, 3H), 2.97 (dd, 2H)。
參考文獻(xiàn)：
[1] European Journal of Organic Chemistry, 2003, # 17, p. 3387 - 3397
[2] Patent: WO2012/148246, 2012, A2. Location in patent: Page/Page column 16
[3] Tetrahedron Letters, 2003, vol. 44, # 28, p. 5251 - 5253
[4] Journal of Organic Chemistry, 2009, vol. 74, # 11, p. 4177 - 4187
[5] Tetrahedron Asymmetry, 2011, vol. 22, # 20-22, p. 1849 - 1854
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/05/22 | H63642 | CBZ-ASP(OME)-OH N-Benzyloxycarbonyl-L-aspartic acid 4-methyl ester, 98% | 3160-47-2 | 5g | 1349元 |
| 2025/05/22 | HY-W011553 | CBZ-ASP(OME)-OH Z-Asp(OMe)-OH | 3160-47-2 | 10 g | 130元 |
| 2025/05/22 | HY-W011553 | CBZ-ASP(OME)-OH Z-Asp(OMe)-OH | 3160-47-2 | 25 g | 322元 |