31181-90-5
31181-90-5 結(jié)構(gòu)式
基本信息
5-溴-吡啶-2-甲醛
5-溴-2-甲?；?/span>
5-BROMO-2-PYRIDINECARBALDEHYDE
5-BROMO-2-PYRIDINECARBOXALDEHYDE
5-BROMOPICOLINALDEHYDE
5-BROMO-PYRIDINE-2-CARBALDEHYDE
5-BROMOPYRIDINE-2-CARBOXALDEHYDE
2-Formyl-5-Bromopyridine
5-Bromopyridine-2-carboxaldehyde 95%
2-FORMYL-5-BROMOPYRIDINE / 5-BROMO-2-FORMYLPYRIDINE
5-BROMO-2-PYRIDINECARBOXALDEHYDE / 5-BROMONICOTINALDEHYDE
5-BROMOPYRIDINE-2-CARBALDEHYDE(MFCD04112535)
5-Bromo-2-formylpyridine, 5-Bromo-2-picolinaldehyde
5-Bromo-2-picolinaldehyde
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
624-28-2
68-12-2
31181-90-5
以2,5-二溴吡啶和N,N-二甲基甲酰胺(DMF)為原料，按照通用方法C合成5-溴-2-吡啶甲醛。具體操作如下：將2,5-二溴吡啶(237 mg, 1 mmol)與DMF(115 μL, 1.5 mmol)混合反應(yīng)。反應(yīng)完成后，通過(guò)快速柱色譜法(洗脫劑：己烷/乙酸乙酯=10:1)純化粗產(chǎn)物，得到目標(biāo)化合物5-溴-2-吡啶甲醛(27b)，為褐色固體(149 mg, 產(chǎn)率80%)。薄層色譜(TLC)分析顯示Rf值為0.45(展開(kāi)劑：己烷/乙酸乙酯=8:1)。核磁共振氫譜(1H NMR, 400 MHz, CDCl3)數(shù)據(jù)如下：δ 10.03 (1H, s), 8.85 (1H, dd, J = 0.8, 2.0 Hz), 8.02 (1H, ddd, J = 0.8, 2.0, 8.0 Hz), 7.85 (1H, dd, J = 0.8, 8.0 Hz)。核磁共振碳譜(13C NMR, 100 MHz, CDCl3)數(shù)據(jù)如下：δ 192.4, 151.7, 151.3, 140.0, 126.3, 122.8。所得光譜數(shù)據(jù)與文獻(xiàn)報(bào)道一致。
參考文獻(xiàn)：
[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5852 - 5869
[2] Patent: WO2007/15744, 2007, A1. Location in patent: Page/Page column 58-59
[3] Chemistry - A European Journal, 2006, vol. 12, # 13, p. 3472 - 3483
[4] Patent: WO2006/22794, 2006, A1. Location in patent: Page/Page column 49
[5] Tetrahedron Letters, 2000, vol. 41, # 22, p. 4335 - 4338
上下游產(chǎn)品信息
知名試劑公司產(chǎn)品信息
5-bromopyridine-2-carbaldehyde(31181-90-5)