175463-32-8
175463-32-8 結(jié)構(gòu)式
基本信息
3-氰基-4-氧代吡咯烷-1-甲酸叔丁酯
1-N-BOC-3-氰基-吡咯烷酮
1-N-叔丁氧羰基-4-氰基-3-吡咯烷酮
4-氧-3-氰基-1-N-BOC-吡咯烷
1-BOC-3-氰-4-吡咯烷酮,98%
1-N-BOC-3-CYANO-PYRROLID-4-ONE
1-N-BOC-3-CYANO-PYRROLIDINONE-4
1-N-BOC-3-CYANO-PYRROLIDONE-4
1-N-BOC-4-CYANO-PYRROLIDINE-3-ONE
3-CYANO-4-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-CYANO-1-N-BOC PYRROLIDIN-3-ONE
N-BOC-3-CYANO-4-PYRROLIDINONE
TERT-BUTYL-3-CYANO-4-OXOPYRROLIDINE-1-CARBOXYLATE
1-Boc-3-Cyano-4-pyrrolidinone
1-N-BOC-3-CYANOPYRROLIDIN-4-ONE
1-N-Boc-3-cyano-pyrrolidone-4 ,97%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
266353-18-8
175463-32-8
以2-(BOC-(2-氰基乙基)氨基)乙酸乙酯為原料合成1-Boc-3-氰基-4-吡咯烷酮的一般步驟：將油狀物2-(BOC-(2-氰基乙基)氨基)乙酸乙酯（16.5g）溶于50mL無(wú)水乙醇中。在加熱回流條件下，將該溶液緩慢滴加到含有4g（0.17mol）金屬鈉的100mL無(wú)水乙醇溶液中，繼續(xù)回流反應(yīng)1小時(shí)。反應(yīng)完成后，減壓蒸餾除去溶劑。殘余物用100mL水溶解，隨后用乙酸乙酯（30mL×2）洗滌水層。用1mol/L鹽酸調(diào)節(jié)水層pH至4，再用乙酸乙酯萃取。有機(jī)相用無(wú)水硫酸鎂干燥，過(guò)濾。將濾液濃縮至約20mL，過(guò)濾后，用少量乙酸乙酯洗滌濾餅，干燥后得到16.5g白色固體1-Boc-3-氰基-4-吡咯烷酮，收率為68%。
參考文獻(xiàn)：
[1] Archiv der Pharmazie, 2011, vol. 344, # 8, p. 523 - 529
[2] European Journal of Medicinal Chemistry, 2010, vol. 45, # 11, p. 5498 - 5506
[3] Patent: CN105585518, 2016, A. Location in patent: Paragraph 0024; 0026
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 22, p. 3584 - 3593
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4399 - 4403
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | H29306 | 1-Boc-3-氰-4-吡咯烷酮,97% 1-Boc-3-cyano-4-pyrrolidinone, 97% | 175463-32-8 | 5g | 2804元 |
| 2025/05/22 | XW1754633283 | 1-BOC-3-氰基-4-吡咯烷酮 1-(tert-butoxycarbonyl)-3-cyano-4-pyrrolidinone;1-tert-butoxycarbonyl-3-cyano-4-pyrrolidinone;1-tert-butoxycarbonyl-3-cyano-4-pyrrolidone;1-boc-3-cyano-4-pyrrolidinone;1-boc-3-cyano-4-pyrrolidone;1-boc-3-cyano-4-oxopyrrolidine;tert-butyl 3-cyano-4-oxopyrrolidine-1-carboxylate;3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester | 175463-32-8 | 5G | 40元 |
| 2025/05/22 | B4761 | 1-叔丁氧羰基-3-氰基-4-吡咯烷酮 1-tert-Butoxycarbonyl-3-cyano-4-pyrrolidone | 175463-32-8 | 1g | 60元 |