120737-59-9

基本信息
4-叔丁氧羰基-2-甲基-哌嗪
1-BOC-3-甲基哌嗪
4-N-Boc-2-甲基哌嗪
4-N-BOC-2-甲基哌嗪
3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-BOC-2-METHYL PIPERAZINE
4-N-BOC-2-METHYL-PIPERAZINE
N-1-BOC-3-METHYL PIPERAZINE
(+/-)-N4-BOC-2-METHYLPIPERAZINE
tert-Butyl 3-methylpiperazine-1-carboxylate
1-Boc-3-methyl-piperazine
N-1-BOC-3-METHYL PIPERIZINE
1-N-Boc-3-methylpiperizine
2-Methylpiperazine, N4-BOC protected
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法

24424-99-5

109-07-9

120737-59-9
以二碳酸二叔丁酯和2-甲基哌嗪為原料合成4-叔丁氧羰基-2-甲基哌嗪的一般步驟:1)在室溫條件下,將二碳酸二叔丁酯(21.7g)緩慢加入至2-甲基哌嗪(10.0g)的甲醇(200mL)溶液中,隨后持續(xù)攪拌反應(yīng)混合物24小時(shí)。反應(yīng)完成后,通過減壓蒸餾除去甲醇溶劑。所得粗產(chǎn)物采用硅膠柱色譜法(洗脫劑:氯仿-甲醇混合溶劑)進(jìn)行純化,最終得到3-甲基哌嗪-1-羧酸叔丁酯,為無色油狀產(chǎn)物(19.3g,收率96.5%)。產(chǎn)物經(jīng)1H-NMR(300MHz,CDCl3)表征:δ1.04(3H,d,J=6.24Hz),1.46(9H,s),2.39(1H,br s),2.70-2.77(3H,m),2.94(1H,br s),3.93(2H,br s)。質(zhì)譜分析(FAB)顯示分子離子峰M/Z:201(M+H)+。
參考文獻(xiàn):
[1] Patent: US2003/153556, 2003, A1
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 33
[3] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00286
[4] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 19
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5432 - 5448
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/05/22 | H52809 | (+/-)-1-Boc-3-甲基哌嗪, 97% (±)-1-Boc-3-methylpiperazine, 97% | 120737-59-9 | 5g | 931元 |
2025/05/22 | H52809 | (+/-)-1-Boc-3-甲基哌嗪, 97% (±)-1-Boc-3-methylpiperazine, 97% | 120737-59-9 | 25g | 4657元 |
2025/05/22 | XW0212073759904 | 4-叔丁氧羰基-2-甲基哌嗪 | 120737-59-9 | 100G | 498元 |