120511-84-4
120511-84-4 結(jié)構(gòu)式
基本信息
5-溴甲基-a,a,a',a'-四甲基-1,3-二乙氰基苯
5-溴甲基-四甲基-1,3-二乙氰基苯
阿那曲唑中間體 2
3,5-Bis(2-cyanoprop-2-yl)benzyl bromide
5-(BROMOMETHYL)-A,A,A,A-TETRAMETHYL-1,3-BENZENEDIACETONITRILE
5-BROMOMETHYL-A,A,A',A'-TETRAMETHYL-1,3-BENZENEDIACETONITRILE
5-(BROMOMETHYL)-ALPHA,ALPHA,ALPHA,ALPHA-TETRAMETHYL-1,3-BENZENEDIACETONITRILE
5-BROMOMETHYLTETRAMETHYL-1,3-BENZENEDIACETONITRILE
2,2'-(5-BROMOMETHYL-1,3-PHENYLENE)-DI-(2-METHYLPROPIONITRILE)
5-BROMOMETHYL-A,A,A',A'-TETRAMETHYL-1,3-BENZENEDIACETONITRIL
3,5-Bis(1-Cyano-1-Methylethyl)BromomethylBenezene(ForAnastrozole)
3,5-Bis(1-cyano-1-methylethyl)bromomethylbenezene
forAnastrozole
5-(BROMOMETHYI)-A,A,A'',A''-TETRAMETHYI-1,3-BENZENEDIACETONITRILE
2-[3-(Cyanodimethylmethyl)-5-bromomethylphenyl]-2-methylpropionitrile
5-(bromomethyl)-α,α,α',α'-tetramethyl-
2-[3-(Bromomethyl)-5-(1-cyano-1-methylethyl)phenyl]-2-methylpropanenitrile
物理化學(xué)性質(zhì)
常見問題列表
120511-72-0
120511-84-4
以5,α,α,α',α'-五甲基-1,3-苯二乙腈為原料，經(jīng)過步驟III得到3,5-雙（1-氰基-1-甲基乙基）甲苯（600g，2.65mol）。將該產(chǎn)物與N-溴代琥珀酰亞胺（519g，2.916mol）和過氧化苯甲酰（17g，0.053mol）混合于四氯化碳（4.5L）中，回流反應(yīng)2至2.5小時。反應(yīng)完成后，冷卻反應(yīng)混合物并過濾。濾液在40℃至45℃下濃縮至干燥。所得固體在75℃至80℃下溶解于2-丙醇（2L）中，隨后緩慢冷卻至10℃至15℃，并在此溫度下攪拌1小時。進(jìn)一步將反應(yīng)混合物冷卻至-5℃至0℃，繼續(xù)攪拌2小時，之后過濾，并用預(yù)冷的2-丙醇（200ml）洗滌濾餅。濾餅隨后用正己烷洗滌并吸干。最后，將濾餅在40℃至45℃下真空干燥，得到目標(biāo)產(chǎn)物3,5-雙（1-氰基-1-甲基乙基）芐基溴（700.2g，收率87.0%）。
參考文獻(xiàn)：
[1] Patent: US2006/189670, 2006, A1. Location in patent: Page/Page column 5; 7
[2] Patent: US2006/35950, 2006, A1. Location in patent: Page/Page column 3; 11
[3] Patent: CN103554041, 2016, B. Location in patent: Paragraph 0014-0016
[4] Patent: US2009/221837, 2009, A1. Location in patent: Page/Page column 4
[5] Patent: WO2007/39913, 2007, A1. Location in patent: Page/Page column 14