| Identification | More | [Name]
4-FLUOROBENZENESULFINIC ACID SODIUM SALT | [CAS]
824-80-6 | [Synonyms]
NSC 131873
Sodium 4-fL
Fluorobenzaldehyde Sodium
SODIUM P-FLUOROBENZENE SULFINATE
Sodium4fluorobenzenesulfinate,4-FLU
4-FLUOROBENZENESULFINIC ACID SODIUM SALT
p -Fluorobenzenesulfinic Acid Sodium Salt
4-Flurobenzenesulfinic acid sodium salt
Benzenesulfinic acid, 4-fluoro-, sodium salt
p-Fluorobenzenesulfinic Acid Sodium Salt Dihydrate
Sodium4fluorobenzenesulfinate,4-FLUOROBENZENESULFINICACIDSODIUMSALT | [Molecular Formula]
C6H4FNaO2S | [MDL Number]
MFCD03093775 | [Molecular Weight]
182.15 | [MOL File]
824-80-6.mol |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Synthesis]
GENERAL STEPS: In a 250 mL single-necked round-bottomed flask, 4-fluorobenzenesulfonyl chloride (48.5 mmol, 9.4 g, 1.0 eq.), sodium sulfite (97 mmol, 12.2 g, 2.0 eq.), and sodium bicarbonate (97 mmol, 8.1 g, 2.0 eq.) were added in sequence, followed by 60 mL of water. A reflux condenser was installed and the reaction was stirred in an oil bath at 80 °C for 4 hours. Upon completion of the reaction, the water was removed by distillation under reduced pressure and the residue was dissolved in methanol and filtered. The filtrate was concentrated by rotary evaporator to remove methanol, and 10.2 g of sodium p-fluorobenzenesulfinate was obtained as a white solid product with 99% yield. | [References]
[1] Patent: CN107033046, 2017, A. Location in patent: Paragraph 0192; 0193; 0194
[2] Chemistry - An Asian Journal, 2016, vol. 11, # 15, p. 2121 - 2125
[3] Acta Chemica Scandinavica, Series A: Physical and Inorganic Chemistry, 1976, vol. A30, # 8, p. 579 - 585
[4] European Journal of Medicinal Chemistry, 2007, vol. 42, # 6, p. 880 - 884
[5] Journal of Organic Chemistry, 1992, vol. 57, # 9, p. 2594 - 2599 |
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