| Identification | More | [Name]
(S)-(-)-Indoline-2-carboxylic acid | [CAS]
79815-20-6 | [Synonyms]
(R)-1H-INDOLE-2-CARBOXYLIC ACID
(R)-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
(R)-(+)-2,3-DIHYDROINDOLE-2-CARBOXYLIC ACID
(R)-(-)-INDOLINE-2-CARBOXYLIC ACID
(R)-(+)-INDOLINE-2-CARBOXYLIC ACID
(R)-INDOLINE-2-CARBOXYLIC ACID
Perindopril Intermediate
(2S)-indoline-2-carboxylic acid
(2S)-2,3-dihydro-1H-Indole-2-carboxylic acid
(S)-(-)-Indoline-2-CarboxylicAcid98%
S-(-)-Oindolium-2-CarboxylicAcid
(S)-Indoline-2-Carboxylic
1H-Indole-2-carboxylicacid,2,3-dihydro-,(2S)-(9CI)
(S)-(-)-Indoline-2-carboxylic acid
Indoline-2-carboxylic acid
(R)-Indole2-carboxylic Acid
H-L-Idc-OH
1H-Indole-2-carboxylicacid, 2,3-dihydro-, (2S)- | [EINECS(EC#)]
410-860-2 | [Molecular Formula]
C9H9NO2 | [MDL Number]
MFCD00792496 | [Molecular Weight]
163.17 | [MOL File]
79815-20-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
177 °C (dec.)(lit.)
| [alpha ]
-112.5 º (c=1, 1N HCl) | [Boiling point ]
290.25°C (rough estimate) | [density ]
1.2021 (rough estimate) | [refractive index ]
-116 ° (C=1, 2mol/L HCl) | [storage temp. ]
Store at 0°C | [Water Solubility ]
Slightly soluble in water | [form ]
Powder | [pka]
2.04±0.20(Predicted) | [color ]
Beige to brown | [Optical Rotation]
[α]20/D 114°, c = 1 in 1 M HCl | [InChI]
InChI=1S/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)/t8-/m0/s1 | [InChIKey]
QNRXNRGSOJZINA-QMMMGPOBSA-N | [SMILES]
N1C2=C(C=CC=C2)C[C@H]1C(O)=O | [CAS DataBase Reference]
79815-20-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R43:May cause sensitization by skin contact.
R48/22:Harmful: danger of serious damage to health by prolonged exposure if swallowed .
R62:Possible risk of impaired fertility. | [Safety Statements ]
S22:Do not breathe dust .
S25:Avoid contact with eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
2
| [HS Code ]
29339900 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Wy 44221-->1H-Indole-2-carboxylic acid, 1-acetyl-2,3-dihydro-, Methyl ester, (2S)--->(R)-(+)-Indoline-2-carboxylic acid-->L-2-Bromophenylalanine-->1H-Indole-2-carboxylicacid,2,3-dihydro-,methylester,(2S)-(9CI)-->2-Chloro-L-phenylalanine-->2-Bromobenzyl bromide-->Indole-2-carboxylic acid-->1H-Indole-2-carboxylic acid, 2,3-dihydro-, (2S)-, compd. with (αR)-α-methylbenzenemethanamine (1:1)-->Potassium carbonate | [Preparation Products]
Perindopril-->(S)-(+)-2-INDOLINEMETHANOL |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
Catalyst for enantioselective cyclopropanations. | [Synthesis]
Example 1 Synthesis of (S)-2,3-dihydro-1H-indole-2-carboxylic acid: In a 100 mL flask, 366 mg (1.5 mmol) of (S)-2-bromophenylalanine, 217 mg (1.6 mmol) of K2CO3, 3.2 mg (0.03 mmol) of CuCl, and 3.2 g of N-methyl pyrrolidone (NMP) were added in order. ). The reactor was flushed with argon and kept under a slow flow of argon. The reaction mixture was stirred and heated to 100 °C, which was maintained. Samples were taken periodically and analyzed by high performance liquid chromatography (HPLC). after 4 h, (S)-2-bromophenylalanine was completely converted to the target product. （The yield (in solution) of (S)-2,3-dihydro-1H-indole-2-carboxylic acid was 95.9% with an enantiomeric excess (ee) > 98.6%. Example 2 Synthesis of (S)-2,3-dihydro-1H-indole-2-carboxylic acid: 9.76 g (40.0 mmol) of (S)-2-bromophenylalanine, 5.80 g (42.0 mmol) of K2CO3, 40 mg (0.4 mmol) of CuCl, and 40 g of NMP were sequentially added to a flask at 80 °C. The reactor was flushed with argon and then kept under a slow flow of argon. The reaction mixture was stirred and heated to 80 °C, which was maintained. Samples were taken periodically and analyzed by HPLC. after 3.5 h, (S)-2-bromophenylalanine was completely converted. The reaction mixture was cooled to 25 °C, followed by the addition of 40 mL of water and 50 mL of ethyl acetate (EtOAc). The pH of the mixture was adjusted to 3.3 with 3.5 g of a 37% aqueous hydrochloric acid solution. after separation of the phases, the aqueous phase was extracted with 2 x 50 mL of EtOAc. The combined organic layers were washed with 25 mL of saturated aqueous sodium chloride and the organic phase was subsequently concentrated. The residue was dissolved in 16 mL of aqueous 5N hydrochloric acid, and the pH was adjusted to 2.1 with 9.4 g of 32% aqueous sodium hydroxide. the precipitated (S)-2,3-dihydro-1H-indole-2-carboxylic acid was separated by filtration and washed with 2 x 10 mL of water. After drying, 3.24 g (19.8 mmol) of (S)-2,3-dihydro-1H-indole-2-carboxylic acid was obtained in 49.5% yield, ee > 99%. | [References]
[1] Patent: EP1676838, 2006, A1. Location in patent: Page/Page column 16
[2] Patent: EP1676838, 2006, A1. Location in patent: Page/Page column 17
[3] Journal of Organic Chemistry, 2014, vol. 79, # 17, p. 7872 - 7879
[4] Patent: EP1676838, 2006, A1. Location in patent: Page/Page column 16-17
[5] Patent: WO2006/69799, 2006, A1. Location in patent: Page/Page column 28-29 |
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