| Identification | More | [Name]
2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid | [CAS]
65872-41-5 | [Synonyms]
2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETIC ACID
4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-
ATMAA
(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYIMINOACETIC ACID
(Z)-2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINO ACETIC ACID
2-aminothiazole-methoxyiminoaceticacid
2-Methoxylimino-2-(2-aminothiozol)-4-aceticacid
Aminothiaoximinoacid
Aminothiaoximoacid
ATMA
(Z)-2-amino-alpha-(methoxyimino)thiazol-4-acetic acid
(Z)-2-Methoxyimino-2-(2-Amino-Thiazole-4-Yl-)-Acetic Acid Anhydrous
ATMIA
2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(ATMMA)
(Z)-2-methoxyimino-2-(2-aminothiazol-4-yl)Acetic acid anhydrous
(z)-2-(2-Aminothiazol-4-yl)-2-methoxyimino acetic acid Anhydrous
2-AMINO-ALPHA-(METHOXYIMINO)-4-THIAZOLE-ACETIC ACID, 97%, PREDOMINANTLY SYN
AMAA
(Z)-2-(2-Aminothiazol-4-Yl)-2-MethoxyiminoAceticAcidAnhydrous(Atmaa)
Tiotropium Bromide 139404-48-1 (Z)-2-(2-Aminothiazol-4-Yl)-2-Methoxyimino Acetic Acid Anhydrous ( Atmaa ) | [EINECS(EC#)]
265-957-0 | [Molecular Formula]
C6H7N3O3S | [MDL Number]
MFCD00071528 | [Molecular Weight]
201.2 | [MOL File]
65872-41-5.mol |
| Chemical Properties | Back Directory | [Appearance]
OFF-WHITE TO BEIGE POWDER | [Melting point ]
192 °C (dec.)(lit.)
| [Boiling point ]
425.1±37.0 °C(Predicted) | [density ]
1.463 (estimate) | [refractive index ]
1.6630 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
solid | [pka]
2.97±0.10(Predicted) | [color ]
White to Off-White | [Water Solubility ]
0.6 g/100 mL (20 ºC) | [λmax]
273nm(MeOH)(lit.) | [Detection Methods]
T,NMR | [InChI]
InChI=1S/C6H7N3O3S/c1-12-9-4(5(10)11)3-2-13-6(7)8-3/h2H,1H3,(H2,7,8)(H,10,11)/b9-4+ | [InChIKey]
NLARCUDOUOQRPB-RUDMXATFSA-N | [SMILES]
C1(=CSC(N)=N1)/C(/C(=O)O)=N\OC | [CAS DataBase Reference]
65872-41-5(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
OFF-WHITE TO BEIGE POWDER | [Uses]
Intermediate in the preparation of Cephem compounds. | [Synthesis]
General procedure for the synthesis of aminothiazole acid from ethyl (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate (Example 2): in a 250 ml reaction vial, 45.9 g (0.2 mol) of ethyl (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate was suspended in 200 ml of ethanol, followed by the addition of 1 N sodium hydroxide aqueous solution. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7.0 with 10% aqueous hydrochloric acid, followed by distillation under reduced pressure to remove the ethanol. The aqueous phase was washed with ethyl acetate and the pH was adjusted again with 10% aqueous hydrochloric acid to 2.8. Stirring was carried out under cooling conditions in an ice bath to induce the precipitation of crystals. The crystals were separated by filtration, washed with acetone and finally recrystallized from ethanol to give 22.9 g of 2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid in 57.0% yield. | [References]
[1] Patent: EP859002, 1998, A1 |
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