| Identification | More | [Name]
Ethyl 3-aminopropanoate hydrochloride | [CAS]
4244-84-2 | [Synonyms]
3-AMINOPROPIONIC ACID ETHYL ESTER HYDROCHLORIDE
B-ALANINE ETHYL ESTER HCL
B-ALANINE ETHYL ESTER HYDROCHLORIDE
BETA-ALANINE ETHYL ESTER HCL
BETA-ALANINE ETHYL ESTER HYDROCHLORIDE
BETA-ALANINE-OET HCL
ETHYL 3-AMINOPROPANOATE HYDROCHLORIDE
ETHYL 3-AMINOPROPIONATE HYDROCHLORIDE
H-BETA-ALA-OET HCL
TIMTEC-BB SBB004038
β-Alanineethylesterhydrochloride
-Ala-OEt.HCl
H-ß
H-β-Ala-OEt•
ethyl beta-alaninate hydrochloride
H-β-Alanine ethyl ester hydrochloride
SS-ALANINE ETHYL ESTER HYDROCHLORIDE
beta-Alanineethylesterhydrochloride,98+%
H-beta-Ala-Oet
á-alanine ethyl ester hydrochloride | [EINECS(EC#)]
224-203-0 | [Molecular Formula]
C5H12ClNO2 | [MDL Number]
MFCD00012909 | [Molecular Weight]
153.61 | [MOL File]
4244-84-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White to off-white crystalline powder | [Melting point ]
67-70 °C(lit.)
| [storage temp. ]
Store at RT. | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Crystalline Powder | [color ]
White to off-white | [Water Solubility ]
almost transparency | [Sensitive ]
Hygroscopic | [BRN ]
3559095 | [InChI]
InChI=1S/C5H11NO2.ClH/c1-2-8-5(7)3-4-6;/h2-4,6H2,1H3;1H | [InChIKey]
RJCGNNHKSNIUAT-UHFFFAOYSA-N | [SMILES]
C(=O)(OCC)CCN.Cl | [CAS DataBase Reference]
4244-84-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HazardClass ]
HYGROSCOPIC | [HS Code ]
29224900 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white crystalline powder | [Uses]
peptide synthesis | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
Freshly distilled thionyl chloride (250 mL) was slowly added dropwise to stirred anhydrous ethanol (400 mL) at -10 °C. After maintaining the reaction at -10 °C for 20 min, β-alanine (82.56 g, 0.93 mol) was slowly added to the thionyl chloride/ethanol mixture. The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the excess thionyl chloride was removed by distillation and the reaction solution was concentrated to half of the original volume under reduced pressure. The white precipitate precipitated from the concentrate was collected by filtration and washed with cold ether to give a final white crystalline powder of β-alanine ethyl ester hydrochloride (124.34 g, 87% yield). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6200 - 6204
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 6, p. 2336 - 2350
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 11 - 20
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1067 - 1070
[5] Russian Chemical Bulletin, 2017, vol. 66, # 1, p. 136 - 142 |
|
|