Identification | Back Directory | [Name]
TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE | [CAS]
167263-04-9 | [Synonyms]
tert-Butyl 4-cyano-4-(pyridin-2-yl) 1-Boc-4-cyano-4-(2-pyridinyl)-piperidine TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE 1-Piperidinecarboxylic acid, 4-cyano-4-(2-pyridinyl)-, 1,1-diMethylethyl ester | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C16H21N3O2 | [MDL Number]
MFCD11227109 | [MOL File]
167263-04-9.mol | [Molecular Weight]
287.36 |
Chemical Properties | Back Directory | [Boiling point ]
444.6±45.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
5.43±0.19(Predicted) | [InChI]
InChI=1S/C16H21N3O2/c1-15(2,3)21-14(20)19-10-7-16(12-17,8-11-19)13-6-4-5-9-18-13/h4-6,9H,7-8,10-11H2,1-3H3 | [InChIKey]
OUILGYJQVAMETA-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(C#N)(C2=NC=CC=C2)CC1 |
Hazard Information | Back Directory | [Synthesis]
Sodium hydride (60% dispersed in mineral oil, 2.04 g, 51 mmol) was added in batches to a stirred solution of 2-pyridineacetonitrile (1.8 mL, 17 mmol) and tert-butyl N,N-bis(2-chloroethyl)carbamate (in appropriate amounts) in anhydrous DMF (50 mL) under nitrogen protection, and the temperature of the reaction was maintained at 0°C. The reaction was carried out in a controlled manner. The addition process was controlled to be completed within 8 min. Subsequently, the reaction system was warmed up to 60 °C and the reaction was continuously stirred for 5.5 hours. After completion of the reaction, the mixture was cooled to room temperature, extracted with ethyl acetate (4 x 150 mL), the organic phases were combined and washed with water (3 x 200 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give a red to black oily crude product. The crude product was adsorbed on silica gel and purified by column chromatography with the eluent being an isohexane solution of 20% ethyl acetate to give tert-butyl 4-cyano-4-(pyridin-2-yl)piperidine-1-carboxylate as an orange solid (2.13 g, 44% yield). The structure of the product was confirmed by 1H NMR (360 MHz, CDCl3): δ 1.48 (9H, s), 2.04-2.08 (2H, m), 2.17-2.25 (2H, m), 3.15-3.28 (2H, m), 4.20-4.35 (2H, m), 7.25-7.29 (1H, m), 7.61 (1H, d, J = 8 Hz), 7.73-7.78 (1H, m), 8.61 (1H, dd, J = 0.7, 3.9 Hz). The mass spectrum (MS) showed [M+H]+ m/z = 287 (corresponding to the loss of the tert-butyl fragment, -56). | [References]
[1] Patent: WO2005/51390, 2005, A1. Location in patent: Page/Page column 28 [2] Bioorganic and medicinal chemistry letters, 2000, vol. 10, # 15, p. 1625 - 1628 [3] Patent: US5635510, 1997, A [4] Patent: US5824690, 1998, A |
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