| Identification | More | [Name]
tert-Butyl 2,6-dichloroisonicotinate | [CAS]
75308-46-2 | [Synonyms]
2,6-dichloro-4-pyridinecarboxylic acid 1,1-dimethylethyl ester
2,6-Dichloroisonicotinic acid tert-butyl ester
tert-Butyl 2,6-dichloro-4-pyridinecarboxylate
TERT-BUTYL 2,6-DICHLOROISONICOTINATE
2,6-Dichloroisonicotinic Acid t-butyl ester | [Molecular Formula]
C10H11Cl2NO2 | [MDL Number]
MFCD08445655 | [Molecular Weight]
248.11 | [MOL File]
75308-46-2.mol |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 2,6-dichloroisonicotinic acid (2 g, 10.4 mmol) in toluene (50 mL) N, N- dimethylformamide di-fert-butil acetal (15 mL, 62.5 mmol) was added under nitrogen atmosphere and mixture heated at 80°C overnight. Ethyl acetate was added, and the organic layer was washed with water and brine, dried (MgS04), filtered and concentrated to yield tert-Butyl 2,6-dichloroisonicotinate (2.34 g, 87 per cent) as a solid. | [References]
[1] Patent: WO2008/11499, 2008, A1. Location in patent: Page/Page column 37-38
[2] Organic Process Research and Development, 2009, vol. 13, # 6, p. 1145 - 1155
[3] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 79 |
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