| Identification | More | [Name]
1-Boc-4-Methylaminopiperidine | [CAS]
147539-41-1 | [Synonyms]
1-BOC-4-METHYLAMINOPIPERIDINE
1-N-BOC-4-(METHYLAMINO)PIPERIDINE
4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-N-METHYLAMINO-1-BOC-PIPERIDINE
BUTTPARK 90\06-11
N-BOC-4-METHYLAMINOPIERIDINE
N-BOC-4-METHYLAMINOPIPERIDINE
N-BOC-4-N-METHYLAMINO PIPERIDINE
tert-butyl 4-(methylamino)piperidine-1-carboxylate
1-Boc-4-methylaminopieridine
1-TERT-BUTYLOXYCARBONYL-4-AMINOMETHYL-PIPERIDINE
1-Piperidinecarboxylic acid, 4-(methylamino)-, 1,1-dimethylethyl ester
1-Boc-4-methyl-aminopiperidine
tert-butyl 4-(methylamino)piperidine-1-carboxylate
1-BOC-4-METHYLAMINOPIPERIDINE, 98+%
1-t-Butyloxycarbonyl-4-(aminomethyl)-piperidine hydrochloride
4-(Methylamino)piperidine, N1-BOC protected | [Molecular Formula]
C11H22N2O2 | [MDL Number]
MFCD02259411 | [Molecular Weight]
214.3 | [MOL File]
147539-41-1.mol |
| Chemical Properties | Back Directory | [Boiling point ]
289.0±33.0 °C(Predicted) | [density ]
1.005 g/mL at 25 °C | [refractive index ]
n20/D1.468 | [Fp ]
>110℃ | [storage temp. ]
2-8°C | [form ]
clear liquid | [pka]
10.19±0.20(Predicted) | [color ]
Colorless to Almost colorless | [Detection Methods]
GC | [InChI]
InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-9(12-4)6-8-13/h9,12H,5-8H2,1-4H3 | [InChIKey]
CZYUGTLMFHDODF-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(NC)CC1 | [CAS DataBase Reference]
147539-41-1(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2810 | [WGK Germany ]
3
| [F ]
10-34 | [HazardClass ]
6.1 | [PackingGroup ]
Ⅲ | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Uses]
1-Boc-4-(methylamino)piperidine is used as an organic chemical synthesis intermediate. | [Synthesis]
GENERAL STEPS: To a suspension of N-Boc-4-piperidone (10.00 g, 50.19 mmol) in ethanol (75 mL) was added 10% Pd/C catalyst (1.00 g, 10 wt%), methylamine (33% ethanol solution, 27 mL, 0.20 mol) and formic acid (46 mg, 1.00 mmol). The reaction mixture was placed in an autoclave, sealed under a hydrogen atmosphere at 4 MPa and stirred at 50°C overnight. After completion of the reaction, it was cooled to room temperature and filtered to remove the catalyst. The filtrate was concentrated in vacuum to afford 1-Boc-4-(methylamino)piperidine as a pale yellow liquid (10.70 g, 99% yield). Mass spectrum (ESI, cation mode) m/z: 215.3 [M + H]+; 1H NMR (400 MHz, CDCl3): δ (ppm) 4.01 (m, 2H), 2.79 (m, 2H), 2.48 (m, 1H), 2.42 (s, 3H), 1.83 (m, 2H), 1.44 (s, 9H), 1.28-1.15 (m, 2H). | [References]
[1] Patent: WO2015/73267, 2015, A1. Location in patent: Paragraph 332
[2] Patent: CN104650092, 2017, B. Location in patent: Paragraph 0533-0536
[3] Patent: US2006/160786, 2006, A1. Location in patent: Page/Page column 32
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 17, p. 4281 - 4285
[5] Patent: WO2005/7645, 2005, A1. Location in patent: Page 77 |
|
|