| Identification | Back Directory | [Name]
TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE | [CAS]
91419-48-6 | [Synonyms]
4-carbamoyL
BUTTPARK 95\06-10
N-BOC isonipecotamide
1-N-BOC-ISONIPECOTAMIDE
1-Boc-4-carbamoylpiperidine
N-BOC-4-PieridinecarboxaMide
Boc-piperidine-4-carboxylate
N-BOC-4-PiperidineCarboxamide
1-Boc-4-Piperidinecarboxamide
N-BOC-piperidine-4-carboxamide
1-BOC-piperidine-4-carboxamide
1-N-Boc-4-piperidinecarboxamide
1-N-BOC-PIPERIDINE-4-CARBOXAMIDE
1-Boc-4-(aMinocarbonyl)-piperidine
N-boc - piperidine -4- carboxylamide
4-Carbamoylpiperidine, N1-BOC protected
tert-butyl 4-carbaMoylpiperidine-1-carboxylate
tert-Butyl 4-Carbamoyl-1-piperidinecarboxylate
1-(tert-Butoxycarbonyl)-4-piperidinecarboxaMide
1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXAMIDE
tert-butyl N-[(piperidin-4-yl)carbonyl]carbaMate
1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide >
tert-Butyl 4-carbaMoylpiperidine-1-carboxylate,97+%
tert-Butyl 4-(aminocarbonyl)-piperidine-1-carboxylate
4-CarbaMoyl-piperidine-1-carboxylicacidtert-butylester
4-Carbamoyl-1-piperidinecarboxylic Acid tert-Butyl Ester
1-TERT-BUTYLOXYCARBONYL PIPERIDINE-4-CARBOXYLIC ACIDAMIDE
tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1-carboxylate
Tert-butyl 4-(aMinocarbony)tetrahydropyridine-1 (2H)-carboxylate
TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE
1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-, 1,1-dimethylethyl ester
tert-Butyl 4-carbamoylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-carbamoylpiperidine, 1-(tert-Butoxycarbonyl)piperidine-4-carboxamide | [EINECS(EC#)]
-0 | [Molecular Formula]
C11H20N2O3 | [MDL Number]
MFCD02180953 | [MOL File]
91419-48-6.mol | [Molecular Weight]
228.29 |
| Chemical Properties | Back Directory | [Melting point ]
158-160 | [Boiling point ]
384.4±31.0 °C(Predicted) | [density ]
1.123±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
16.40±0.20(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C11H20N2O3/c1-11(2,3)16-10(15)13-6-4-8(5-7-13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14) | [InChIKey]
YHFUWPUJUMZXBD-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(C(N)=O)CC1 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
General procedure for the synthesis of tert-butyl 4-carbamoylpiperidine-1-carboxylate from 1-Boc-4-piperidinecarboxylic acid: a mixture of 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (220 mg, 2.88 mmol), ammonium chloride (154 mg, 2.88 mmol), EDCI (367 mg, 1.92 mmol) and HOAT (195 mg. 1.44 mmol) were dissolved in dichloromethane (10 mL) at 0 °C, followed by dropwise addition of DIPEA (1.0 mL, 5.77 mmol). After dropwise addition, the reaction mixture was stirred at room temperature for 10 hours. After completion of the reaction, the reaction mixture was washed with distilled water (10 mL x 3). The organic layer was separated and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate as eluent to afford tert-butyl 4-carbamoylpiperidine-1-carboxylate as a white solid (160 mg, 73% yield).1H NMR (400 MHz, CD3OD): δ 4.11 (d, J = 13.4 Hz, 2H), 2.76-2.86 (m, 2H), 2.38-2.45 ( m, 1H), 1.79 (d, J = 11.2 Hz, 2H), 1.52-1.62 (m, 2H), 1.47 (s, 9H).MS-ESI: m/z 173.20 [M-55]+. | [References]
[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00539
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1621-1623
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9196 - 9213
[4] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 114
[5] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 181 - 186 |
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