| Identification | More | [Name]
5-Indolylboronic acid | [CAS]
144104-59-6 | [Synonyms]
1H-INDOL-5-YLBORONIC ACID
1H-INDOLE-5-BORONIC ACID
5-INDOLEBORONIC ACID
5-INDOLYLBORONIC ACID
AKOS BRN-0120
INDOLE-5-BORONIC ACID
RARECHEM AH PB 0158
5-Indole Boric Acid
5-Indolyboronic acid
5-INDOYLBORONIC ACID
5-Indolylboronic
5-INDOLYLBORONIC ACID 97%
5-INDOLBORONIC ACID | [Molecular Formula]
C8H8BNO2 | [MDL Number]
MFCD01319013 | [Molecular Weight]
160.97 | [MOL File]
144104-59-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White to light yellow crystal powde | [Melting point ]
170-175 °C | [Boiling point ]
433.2±37.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
0-6°C | [form ]
Crystalline Powder | [pka]
8.91±0.30(Predicted) | [color ]
White | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
144104-59-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R21/22:Harmful in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant/Keep Cold | [HazardClass ]
IRRITANT, KEEP COLD | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow crystal powde | [Uses]
Reactant involved in the synthesis of biologically active molecules including:
- Indole inhibitors of MMP-13 for arthritic disease treatment
- Substituted pyrimidines acting as tubulin polymerization inhibitors
Reactant involved in Suzuki coupling reactions for synthesis of
- Aryl- hetarylfurocoumarins
- Aryl-substituted oxabenzindoles and methanobenzindoles
Reactant involved in:
- Oxidative cross-coupling with mercaptoacetylenes
- Trifluoromethylation
| [Uses]
Indole-5-boronic acid is a useful reagent for palladium and copper catalyzed oxidative cross-coupling of mercaptoacetylenes and arylboronic acids. A reagent used in the synthesis of other biologically active molecules. | [General Description]
May contain varying amounts of anhydride | [Synthesis]
General procedure for the synthesis of 5-bromoindole and triisopropyl borate as raw materials for the synthesis of 5-bromoindoleboronic acid: In a dry and nitrogen-protected three-necked flask, anhydrous THF (80 mL) solution of NaH (1.02 g, 42.5 mmol) was added, equipped with a magnetic stirrer and a septum. The reaction system was cooled to 0 °C under N2 atmosphere and 5-bromoindole (5.0 g, 25.5 mmol) was added slowly dropwise, and stirring was continued for 15 min after completion of the dropwise addition. Subsequently, n-BuLi (2.5 M hexane solution, 15 mL, 37.5 mmol) was added slowly and stirred for 10 min. Then, triisopropyl borate (22 mL, 51 mmol) was added dropwise. After completion of the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirred overnight, and stirring was continued for 2 hours. After completion of the reaction, the reaction was quenched with saturated NH4Cl solution and stirred for 30 minutes. The organic layer was separated and the aqueous layer was extracted with EtOAc. The organic layers were combined, washed sequentially with water and brine and dried over Na2SO4. After complete removal of the solvent, the residue was treated with EtOAc/petroleum ether and filtered to afford the target product 1H-indol-5-ylboronic acid (b1) as a colorless solid (1.02 g, 25% yield). The structure of the product was determined by 1H-NMR (DMSO-d6) δ 11.1 (s, 1H), 8.30 (s, 1H), 7.81 (d, 1H, J = 8.1 Hz), 7.47 (d, 1H, J = 8.1 Hz), 7.34 (s, 1H) and 13C-NMR (100 MHz, DMSO-d6) δ 138.0, 128.0, 127.5, 127.4, 127.3, 125.4, 111.0, 102.0 confirmed. | [References]
[1] Tetrahedron Letters, 2017, vol. 58, # 1, p. 35 - 42 |
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