| Identification | More | [Name]
3-HYDROXY-4-PYRIDINECARBOXYLIC ACID | [CAS]
10128-71-9 | [Synonyms]
3-HYDROXY-4-PYRIDINECARBOXYLIC ACID
3-HYDROXYISONICOTINIC ACID
3-HYDROXY PYRIDINE-4-CARBOXYLIC ACID
3-Hydroxy-4-pyridinecaboxylic acid
3-Hydroxy-4-pyridinecarboxylic acid ,97% | [Molecular Formula]
C6H5NO3 | [MDL Number]
MFCD00234165 | [Molecular Weight]
139.11 | [MOL File]
10128-71-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
317-319(dec.) | [Boiling point ]
519.3±35.0 °C(Predicted) | [density ]
1.485±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Solid | [pka]
0.51±0.10(Predicted) | [color ]
Light yellow to Brown | [Water Solubility ]
Soluble in methanol. Slightly soluble in water. | [Detection Methods]
HPLC | [CAS DataBase Reference]
10128-71-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Uses]
3-Hydroxyisonicotinic Acid is used in the preparation of chelating agents for iron and aluminum. | [Synthesis]
Step B: Synthesis of 3-hydroxyisonicotinic acid: 3-aminoisonicotinic acid (108.86 g, 788.13 mmol) was dissolved in water (1740 mL), followed by slow addition of sulfuric acid (84.020 mL, 1576.3 mmol). The resulting yellow slurry was cooled to below 10°C and a solution of sodium nitrite (60.359 g, 874.83 mmol) in water (510 mL) was added dropwise while maintaining the temperature below 10°C. Subsequently, the reaction mixture was heated to 80°C, at which point a large amount of precipitate generation was observed. After the suspension was cooled to 65°C, glacial acetic acid (88 mL, continuous decantation) and concentrated ammonium hydroxide (190 mL) were added sequentially to adjust the final pH to about 4.5. The precipitate was collected by vacuum filtration and washed with cold water. The solid was dried in air for 16 h to give the final free flowing granular 3-hydroxyisonicotinic acid (99.37 g, 91% yield). | [References]
[1] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 78; 30
[2] Patent: WO2008/24725, 2008, A1. Location in patent: Page/Page column 67
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 6942 - 6990 |
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