RESIQUIMOD synthesis
- Product Name:RESIQUIMOD
- CAS Number:144875-48-9
- Molecular formula:C17H22N4O2
- Molecular Weight:314.38
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Yield:144875-48-9 1.5 g
Reaction Conditions:
with ammonia in methanol at 160; for 8 h;Sealed tube;Autoclave;
Steps:
7 Preparation of R-848
Preparation of R-848 A mixture of compound 2-6 (1.87 g, 5.3 mmol) in N113/MeOH was sealed in an autoclave and stirred at 160°C for 8 hrs. Then the solvent was removed and the residue was purified by silica gel column chromatography (EA / TEA 95: 5). The desired product R-848 (1.5 g) was obtained.
References:
WO2013/67597,2013,A1 Location in patent:Page/Page column 80
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