ChemicalBook CAS DataBase List N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline synthesis

5synthesis methods

Product Name:N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
CAS Number:70627-52-0
Molecular formula:C20H16FNO
Molecular Weight:305.35

4397-53-9

371-40-4

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

70627-52-0

General procedure for the synthesis of 4-benzylbenzylidene-(4-fluoro)aniline from 4-benzyloxybenzaldehyde and 4-fluorobenzenamine: 4-fluorobenzylidene-(4-fluoro)aniline (100 g, 1.1 eq.) was mixed with isopropanol (1730 ml, 10 V) and heated under mechanical stirring up to 40 °C, whereby a large amount of light yellow crystalline solid was gradually precipitated. Stirring was continued and the reaction was monitored until completion. The heating was stopped and the reaction was cooled naturally to room temperature with stirring. Extraction and filtration operations were carried out, and the filter cake was washed with cold isopropanol and dried to give the light yellow crystalline product SM 2 with a mass of 238 g, 95% yield and 99% purity.

4397-53-9
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$8.00/10g

371-40-4 Synthesis

371-40-4
406 suppliers
$5.00/5 g

70627-52-0
215 suppliers
$5.00/1g

Yield: 95%

Reaction Conditions:

in isopropyl alcohol at 40;

Steps:

2 Preparation of compound SM2
P-Fluoroaniline (100 g, 1.1 eq) and isopropanol (1730 ml, 10 V) were added and heated to 40 ° C. with mechanical stirring to precipitate a large amount of a pale yellow crystalline solid gradually, Stir over time and monitor until reaction is complete. The heating was stopped, the temperature was naturally lowered to room temperature while stirring, extraction and filtration were carried out, the filter cake was washed off with cold isopropanol, and after drying, a pale yellow crystalline substance SM 2 was obtained, the mass was 238 g , The yield is 95%, and the purity is 99%.

References:

Pharmaceutical Technology Co., Ltd.;Li, Wen Sun JP2016/147843, 2016, A Location in patent:Paragraph 0016