N-(2-broMophenyl)-N-Methyl-MethanesulfonaMide synthesis
- Product Name:N-(2-broMophenyl)-N-Methyl-MethanesulfonaMide
- CAS Number:553652-34-9
- Molecular formula:C8H10BrNO2S
- Molecular Weight:264.14
116547-91-2
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74-88-4
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553652-34-9
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Yield:553652-34-9 98%
Reaction Conditions:
with caesium carbonate in acetonitrile at 20; for 24 h;
Steps:
196.196b
To a suspension of N-(2-bromo-phenyl)-methanesulfonamide (5.01 g, 20.0 mmol) and cesium carbonate (7.2 g, 22 mmol) in acetonitrile (20 mL) was added iodomethane (1.4 mL, 22 mmol). The mixture was stirred at room temeprature for 24 hours then diluted with dichloromethane (30 mL), filtered through a plug of diatomaceous earth and evaporated. N-(2-Bromo-phenyl)-N-methyl-methanesulfonamide was isolated as a pale orange solid (5.22 g, 98%). 1H NMR (400 MHz, CDCl3, δ, ppm): 7.65 (d, J=8.0 Hz, IH), 7.50 (d, J=7.9 Hz, IH), 7.37 (t, J=7.4 Hz, IH), 7.23 (t, J=8.2 Hz, IH), 3.29 (s, 3H), 3.06 (s, 3H). MS = 286, 288 (MH)+.
References:
WO2010/141796,2010,A2 Location in patent:Page/Page column 276
615-36-1
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553652-34-9
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$31.00/100mg