Methyl L-isoleucinate hydrochloride synthesis
- Product Name:Methyl L-isoleucinate hydrochloride
- CAS Number:18598-74-8
- Molecular formula:C7H16ClNO2
- Molecular Weight:181.66
67-56-1
73-32-5
18598-74-8
Under ice bath conditions, 1 mL of sulfuryl chloride (SOCl2) was added slowly and dropwise to 5 mL of cooled methanol and the reaction mixture was stirred for 30 minutes. Subsequently, 1.01 g (8.55 mmol) of L-isoleucine was added to the mixture and the reaction was continued with stirring overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by fast column chromatography with an eluent ratio of methanol/ether = 1/5 (v/v), resulting in the colorless oily crystalline product L-isoleucine methyl ester hydrochloride in 98.8% yield. The spectral data of the product were consistent with those reported in the literature.
67-56-1
781 suppliers
$9.00/25ml
17694-98-3
19 suppliers
$505.69/5MG
18598-74-8
292 suppliers
$6.00/5g
Yield:18598-74-8 99%
Reaction Conditions:
with dichloro sulfoxide at 0 - 20;Inert atmosphere;Schlenk technique;
References:
Holzwarth, Marcel;Ludwig, Jan;Bernz, Alexander;Claasen, Birgit;Majoul, Asma;Reuter, Julia;Zens, Anna;Pawletta, Brigitte;Bilitewski, Ursula;Weiss, Ingrid M.;Laschat, Sabine [Organic and Biomolecular Chemistry,2022,vol. 20,# 33,p. 6606 - 6618] Location in patent:supporting information
67-56-1
781 suppliers
$9.00/25ml
73-32-5
965 suppliers
$5.00/250mg
18598-74-8
292 suppliers
$6.00/5g
17901-01-8
38 suppliers
$45.00/10mg
18598-74-8
292 suppliers
$6.00/5g
73-32-5
965 suppliers
$5.00/250mg
75-36-5
592 suppliers
$17.92/100G
18598-74-8
292 suppliers
$6.00/5g
![L-Isoleucine, N-[(phenylmethoxy)carbonyl]-, methyl ester](/CAS/20210305/GIF/42807-91-0.gif)
42807-91-0
0 suppliers
inquiry
18598-74-8
292 suppliers
$6.00/5g