FMOC-L-Methionine synthesis
- Product Name:FMOC-L-Methionine
- CAS Number:71989-28-1
- Molecular formula:C20H21NO4S
- Molecular Weight:371.45
63-68-3
82911-69-1
71989-28-1
Synthesis of Fmoc-L-methionine: 6 mmol of L-methionine and 6.3 mmol of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) were dissolved in 20 mL of N,N-dimethylformamide (DMF). Subsequently, 6.3 mmol of sodium bicarbonate (NaHCO3) was added to the reaction mixture to neutralize the acid produced during the reaction and to remove the solvent and residual amines. The reaction mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified to afford the target compound Fmoc-L-methionine in 78% yield.
63-68-3
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82911-69-1
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71989-28-1
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Yield:71989-28-1 78%
Reaction Conditions:
with sodium hydrogencarbonate in N,N-dimethyl-formamide at 50;
Steps:
S101 Synthesis of Fmoc-methionin
Synthesis of Fmoc-methionine; 6 mmol methionine and6.3 mmol of Fmoc-OSu was added to 20 ml of DMF (N, N-dimethylformamide)Subsequently, 6.3 mmol of NaHCO3 was added to remove the solvent and the remaining amine compound, which was then purified at 50CDried overnight in an empty oven to give 78% product yield;
References:
Southwest Petroleum University;He, Yi;Yang, Ranran;Zhou, Yanqiu;Fan, Yi;Qing, Dayong;Ma, Lan;Zhan, Yingqing;Chen, Zhao CN105622471, 2016, A Location in patent:Paragraph 0019; 0020
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28920-43-6
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71989-28-1
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1131148-55-4
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71989-28-1
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500872-34-4
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88744-04-1
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71989-28-1
437 suppliers
$6.41/1 mmol