Aminopyrazine synthesis
- Product Name:Aminopyrazine
- CAS Number:5049-61-6
- Molecular formula:C4H5N3
- Molecular Weight:95.1
19847-12-2
5049-61-6
General procedure for the synthesis of aminopyrazine from 2-cyanopyrazine: 30 g of 20% sodium hydroxide solution and 100 ml of sodium hypochlorite solution were added to a 500 ml three-necked flask, and 2-cyanopyrazine (21 g, 0.2 mol) was added slowly at room temperature, and the reaction was stirred for 1 hour. Subsequently, the reaction system was warmed up to 50-60°C and the reaction was continued for 4 hours. After completion of the reaction, extraction was carried out with dichloromethane (4 x 200 ml), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and concentrated under reduced pressure to give 15.7 g of white solid product in 82.6% yield.
19847-12-2
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5049-61-6
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Yield:5049-61-6 82.6%
Reaction Conditions:
with sodium hypochlorite;sodium hydroxide at 20 - 60; for 5 h;
Steps:
1 Example 1,Preparation of 2-amino-pyrazine
A 500ml three-neck flask, was added at a concentration of 20% sodium hydroxide (30g) solution, and sodium hypochlorite solution (100ml), was added 2-cyano-pyrazine (21g, 0.2mol) at room temperature, the reaction was stirred for 1h. Then for 4h at 50 ~ 60 , with dichloromethane (4 × 200ml) was extracted, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give a white solid 15.7g, yield 82.6%.
References:
Hubei University of Technology;Liu, Mingxing;Jiang, Weidong;Wang, Wanxia CN105622526, 2016, A Location in patent:Paragraph 0020; 0021; 0022
32111-21-0
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5049-61-6
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94777-52-3
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5049-61-6
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14508-49-7
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5049-61-6
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4949-13-7
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5049-61-6
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$8.00/10g