N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide synthesis
- Product Name:N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide
- CAS Number:960527-22-4
- Molecular formula:C18H18FN3OS2
- Molecular Weight:375.48
108-10-1
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960527-22-4
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Yield:-
Steps:
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
1.2: 4 h / 60 °C
2.1: acetic acid; sodium nitrite / water / 5 h / -5 - 20 °C
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol / 20 °C
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h
4.2: 20 °C
5.1: Lawessons reagent / toluene / 5 h / Reflux
6.1: sodium hydroxide / water; ethanol; tetrahydrofuran / 30 °C
7.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h
7.2: 20 °C
References:
Jia, Haiyong;Yu, Ji;Du, Xianhong;Cherukupalli, Srinivasulu;Zhan, Peng;Liu, Xinyong [European Journal of Medicinal Chemistry,2020,vol. 202,art. no. 112495]
34036-16-3
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960527-22-4
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910475-33-1
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960527-22-4
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