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ChemicalBook >> CAS DataBase List >>N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide

N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide

CAS No.
960527-22-4
Chemical Name:
N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide
Synonyms
NZ-4;W-28-F;W 28 F;Isothiafludine (NZ-4);N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide;[2,2'-Bithiazole]-4-carboxamide, N-[(4-fluorophenyl)methyl]-5-(2-methylpropyl)-
CBNumber:
CB14806359
Molecular Formula:
C18H18FN3OS2
Molecular Weight:
375.48
MDL Number:
MFCD32710181
MOL File:
960527-22-4.mol
Last updated:2025-07-02 13:05:22

N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide Properties

Density 1.287±0.06 g/cm3(Predicted)
pka 13.06±0.46(Predicted)
form Solid
color White to off-white

N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide Chemical Properties,Uses,Production

Description

Isothiafludine, also NZ-4 and W-28-F, is a HBV virus inhibitor that dramatically reduces the HBV DNA level in cells. During the hepatitis B virus (HBV) life cycle, nucleocapsid assembly is essential for HBV replication. Both RNA reverse transcription and DNA replication occur within the HBV nucleocapsid. HBV nucleocapsid is consisted of core protein (HBcAg), whose carboxy-terminal domain (CTD) contains an Arg-rich domain (ARD). The ARD of HBcAg does contribute to the encapsidation of pregenomic RNA (pgRNA).

Uses

Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation[1].

in vivo

Isothiafludine (p.o., 25-100 mg/kg, for 15 days) inhibits DHBV DNA replication in a DHBV-infected duck model[1].

Animal Model:DHBV-infected duck model[2]
Dosage:25-100 mg/kg
Administration:p.o., for 15 days
Result:Inhibited DHBV DNA in the sera on day 15.

References

[1] Yang L, et al. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin. 2014 Mar;35(3):410-8. DOI:10.1038/aps.2013.175

108-10-1
960527-22-4
Synthesis of N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide from 4-Methyl-2-pentanone

N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Tcichem, Inc. 13918644899 tianchong009@hotmail.com China 1817 55
Shanghai Benso Pharmaceutical Technology Co., Ltd. 15088289376 248775804@qq.com China 4990 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12000 58

View Lastest Price from N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Isothiafludine pictures 2025-07-02 Isothiafludine
960527-22-4
 US $293.00-722.00 / mg 99.65% 10g TargetMol Chemicals Inc.
  • Isothiafludine pictures
  • Isothiafludine
    960527-22-4
  • US $293.00-722.00 / mg
  • 99.65%
  • TargetMol Chemicals Inc.
N-(4-fluorobenzyl)-5-isobutyl-2,2'-bithiazole-4-carboxamide Isothiafludine (NZ-4) NZ-4 W 28 F W-28-F [2,2'-Bithiazole]-4-carboxamide, N-[(4-fluorophenyl)methyl]-5-(2-methylpropyl)- 960527-22-4