6-methyl-1H-benzimidazol-7-amine(SALTDATA: FREE) synthesis
- Product Name:6-methyl-1H-benzimidazol-7-amine(SALTDATA: FREE)
- CAS Number:935873-39-5
- Molecular formula:C8H9N3
- Molecular Weight:147.18
32046-84-7
6 suppliers
inquiry
935873-39-5
15 suppliers
$739.77/250MG
Yield:935873-39-5 98%
Reaction Conditions:
with hydrogen;Raney nickel in methanol;ethyl acetate; under 2250.23 Torr; for 18 h;
Steps:
22.1
Step 1: 4-amino-5-methyl-benzimidazole 8.0 g (36 mmol) 5-methyl-4-nitro-benzimidazole are dissolved in 50 ml of ethyl acetate and 50 ml of methanol and combined with 500 mg Raney nickel. The mixture is hydrogenated for 18 hours at 3 bar hydrogen pressure. Then the catalyst is removed by suction filtering and the solvent is eliminated in vacuo. Yield: 5.2 g (98% of theory) C8H9N3 (147.18) MS [ESI (M+H)+]=148
References:
US2007/112033,2007,A1 Location in patent:Page/Page column 30
614-97-1
148 suppliers
$11.00/1g
177843-72-0
18 suppliers
inquiry
935873-39-5
15 suppliers
$739.77/250MG