(6-Methyl-1H-benzimidazol-2-yl)methanol synthesis
- Product Name:(6-Methyl-1H-benzimidazol-2-yl)methanol
- CAS Number:20034-02-0
- Molecular formula:C9H10N2O
- Molecular Weight:162.19
79-14-1
496-72-0
20034-02-0
The Phillips method [1] was used to synthesize (5-methyl-1H-benzimidazol-2-yl)methanol by heating at reflux for 3 h in hydrochloric acid (50 ml, 5.5 M) using 4-methyl-1,2-phenylenediamine (12.22 g; 0.1 mol) and ethanoic acid (11.40 g; 0.15 mol) as raw materials. After completion of the reaction, the mixture was cooled to room temperature, pH was adjusted by addition of aqueous ammonia solution and subsequently cooled in an ice bath until a bright brown precipitate was precipitated. Purification by recrystallization from aqueous ethanol gave (5-methyl-1H-benzimidazol-2-yl)methanol as a light creamy white powdery solid in 100% yield.
79-14-1
832 suppliers
$6.00/25g
496-72-0
319 suppliers
$9.00/1g
20034-02-0
72 suppliers
$39.00/250mg
Yield:20034-02-0 100%
Reaction Conditions:
with hydrogenchloride in water; for 3 h;Reflux;
Steps:
((5-Methyl-1H-benzimidazole-2-yl)-methanol) 25
(5-Methyl-1H-benzimidazole-2-yl)-methanol 25 was prepared using the Phillips procedure [1], 4-Methyl-1,2-phenylenediamine (12.22 g; 0.1 mol) and glycolic acid (11.40 g; 0.15 mmol) in hydrochloric acid (50 ml, 5.5 M) were heated under reflux with for 3 h. The reaction mixture was cooled to room temperature and ammonia solution was added and the mixture cooled in ice until a bright brown precipitate formed. The resulting solid was recrystallised from aqueous ethanol to give (5-methyl-1H-benzimidazole-2-yl)-methanol as a pale creamy powdery solid Yield 100%.
References:
Alasmary, Fatmah A.S.;Snelling, Anna M.;Zain, Mohammed E.;Alafeefy, Ahmed M.;Awaad, Amani S.;Karodia, Nazira [Molecules,2015,vol. 20,# 8,p. 15206 - 15223] Location in patent:supporting information