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ChemicalBook CAS DataBase List 6-FLUOROQUINAZOLIN-4-ONE
16499-56-2

6-FLUOROQUINAZOLIN-4-ONE synthesis

7synthesis methods
2-Amino-5-fluorobenzoic acid

446-08-2

formamide

77287-34-4

6-FLUOROQUINAZOLIN-4-ONE

16499-56-2

General procedure for the synthesis of 6-fluoro-4-hydroxyquinazoline from 2-amino-5-fluorobenzoic acid and the compound (CAS: 77287-34-4): operate with reference to the reaction and post-processing of Example 5, substituting only the type of o-aminobenzoic acid derivative. The specific experimental results are detailed in Table 4.

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Yield: 78%

Reaction Conditions:

with formamide in water

Steps:

3 EXAMPLE 3
A mixture of 2-amino-5-fluorobenzoic acid (2.07 g) and formamide (4 ml) was heated at 160° C. for 2 hours, and for a further 2 hours at 180° C. The reaction mixture was allowed to cool and water was added. The reaction product was filtered off and washed with water and with diethyl ether to give 6-fluoro-3,4-dihydroquinazolin-4-one in 78% yield: m.p. 269-271° C.; Elemental Analysis: Found C, 58.2; H, 3.0; N, 16.9; C8 H4 N2 OF requires C, 58.9; H, 2.5; N, 17.2%.

References:

Zeneca Limited US5955464, 1999, A

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