3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine synthesis

4synthesis methods

Product Name:3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
CAS Number:486460-20-2
Molecular formula:C6H3F3N4
Molecular Weight:188.11

Ethanehydrazonoyl bromide, 2,2,2-trifluoro-N-2-pyrazinyl-

1447800-65-8

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

486460-20-2

General method: 10 mmol of compound 3 (CAS:1447800-65-8) was dissolved in 50 mL of toluene and 20 mmol of triethylamine was slowly added to the reaction system at room temperature with continuous stirring for 1 hour. The reaction process was monitored by thin layer chromatography (TLC). After the reaction was complete, the reaction mixture was slowly poured into 25 g of ice-water mixture, stirred thoroughly and left to stratify. The organic phase was separated and washed with 2 x 10 mL of cold water, followed by drying the organic phase with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give compound 4 in good yield.

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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486460-20-2
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Yield: 90%

Reaction Conditions:

with triethylamine in toluene at 20; for 1 h;

Steps:

General Procedure for Compound 4 (4a, 4b, 4c)
General procedure: (10 mmole) of compound 3 was dissolved in 5 volume of toluene and to this was added (20 mmole) of triethylamine at ambient temperature, and stirred for 1hour. Progress of the reaction was monitored by TLC. After completion of the reaction the reaction mixture was poured on 25g of ice water layers were separated and the organic layer was washed with2X 10ml of cold water dried over sodium sulphate and concentrated to give compound 4 in excellent yield.

References:

Nitlikar, Lakshmikant H.;Darandale, Sunil N.;Shinde, Devanand B. [Letters in Organic Chemistry,2013,vol. 10,# 5,p. 348 - 352]

54608-52-5 Synthesis