2-Chloro-6-hydroxynicotinic acid synthesis
- Product Name:2-Chloro-6-hydroxynicotinic acid
- CAS Number:38025-90-0
- Molecular formula:C6H4ClNO3
- Molecular Weight:173.55
38496-18-3
38025-90-0
The general procedure for the synthesis of 2-chloro-6-hydroxynicotinic acid from 2,6-dichloronicotinic acid is as follows: 1. 2,6-dichloronicotinic acid (25 g, 130 mmol) and NaOH solution (325 mL, 2N) were added to a 500 mL round bottom flask. 2. The reaction mixture was refluxed at 129°C for 4 hours. 3. Upon completion of the reaction, the mixture was cooled to 0°C. 4. The reaction mixture was acidified to room temperature with 6N aqueous HCl solution. 5. The resulting precipitate was collected by filtration. 6. The precipitate was dried under reduced pressure to give 2-chloro-6-hydroxynicotinic acid (19.87 g, 88% yield).
38496-18-3
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38025-90-0
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Yield: 88%
Reaction Conditions:
with water;sodium hydroxide at 129; for 4 h;
Steps:
1.a
Step a 2-chloro-6-oxo-1 ,6-dιhydropyrιdιne-3-carboxylιc acιd; ° A 500-mL round-bottom flask was charged with 2,6-dιchloronιcotιnιc acid (25 0 g 130 mmol), NaOH solution (325 ml_, 2N) and the solution was refluxed at 1290C for 4 hours The reaction mixture was cooled to room temperature and acidified with a 6N aq HCI solution The resulting precipitate was filtered and dried under reduced pressure yielding to the desired product (19 87g, 88%)
References:
Location in patent:Page/Page column 97
262423-77-8
208 suppliers
$9.00/1g
38025-90-0
124 suppliers
$10.00/100mg