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Research in veterinary science

Research in veterinary science

IF: 2.2
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Benzimidazole drugs and modulation of biotransformation enzymes

Published:1 April 2004 DOI: 10.1016/j.rvsc.2003.08.005 PMID: 14672851
J Vel??k , V Baliharová , J Fink-Gremmels , S Bull , J Lamka , L Skálová

Abstract

Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of biotransformation enzymes, research has been carried out mainly due to the initiative of human pharmacologists. The purpose of the present review is to inform about inductive and inhibitive effects of benzimidazole drugs in man, animals and cell cultures. Pharmacological and toxicological consequences of modulation of biotransformation enzymes are discussed and the significance of studies in the field of modulation of biotransformation enzymes in food-producing animals is explained. Since the modulating effect of benzimidazoles strongly varies depending on structure of the individual substances, the particular attention is paid to structure–modulation relationships.

Substances (8)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Albendazole 54965-21-8 C12H15N3O2S 1049 suppliers $16.80-$1714.00
Lansoprazole 103577-45-3 C16H14F3N3O2S 962 suppliers $7.00-$1640.00
Omeprazole 73590-58-6 C17H19N3O3S 852 suppliers $5.00-$1880.00
Fenbendazole 43210-67-9 C15H13N3O2S 696 suppliers $5.00-$1593.90
Mebendazole 31431-39-7 C16H13N3O3 677 suppliers $5.00-$983.88
Thiabendazole 148-79-8 C10H7N3S 542 suppliers $15.00-$1700.00
Oxfendazole 53716-50-0 C15H13N3O3S 445 suppliers $5.00-$1686.30
Pantoprazole 102625-70-7 C16H15F2N3O4S 267 suppliers $29.00-$807.21

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