描述（Description）

PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations.

During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. PDGF can exist either as PDGF-BB or as PDGF-AB or as PDGF-AA where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.PDGF-AA Protein binds to FDGFR and has the potential to enhance bone healing.

純度（Purity）

≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining)

生物活性（Bioactivity）

The Bioactivity is determined by the dose-dependent proliferation of NIH3T3 cells is typically between ≤5.0 ng/mL.

氨基酸序列（Target Protein Sequence）

IEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT

制劑（Trait）

Lyophilized from a 0.2 μm filtered solution of 20 mM Glycine-HCl, 6% Sucrose, 4% Mannitol, 0.02% Tween 80, pH 3.0 or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

復(fù)溶（Reconstitution）

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存條件&效期（Storage & Stability）

Stored at -20°C for 1 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.Please avoid repeated freeze-thaw cycles.

運(yùn)輸方式(Shipping)

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.

Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

特別提示：本公司的所有產(chǎn)品僅用于工業(yè)應(yīng)用或者科學(xué)研究等非醫(yī)療目的,不可用于人類或動(dòng)物的臨床診斷或者治療,非藥用,非食用。