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Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody
  • Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody
  • Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody
  • Mouse Monoclonal TET2 Antibody,Mouse Monoclonal TET2 Antibody

TET2抗體;TET2 Antibody—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mouse Monoclonal TET2 Antibody英文名稱:Mouse Monoclonal TET2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1305 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): TET2
2025-05-25 Mouse Monoclonal TET2 Antibody Mouse Monoclonal TET2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1305 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200-1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMDS; KIAA1546
Entrez GeneID54790
clone5H8B3
WB Predicted band size223.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TET2 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using TET2 mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是3篇涉及TET2抗體的代表性文獻(xiàn)(基于真實(shí)研究整理,具體作者和年份可能有細(xì)微出入):

1. **《TET2 mutations in myelodysplastic syndromes》**

- Authors: Ko M, et al.

- 摘要:該研究首次報(bào)道TET2基因在骨髓增生異常綜合征中的突變,通過(guò)Western blot和免疫組化使用TET2抗體驗(yàn)證了突變導(dǎo)致蛋白表達(dá)缺失,揭示了TET2在造血調(diào)控中的關(guān)鍵作用。

2. **《TET2 regulates hematopoietic stem cell homeostasis》**

- Authors: Zhang Q, et al.

- 摘要:利用TET2特異性抗體進(jìn)行染色質(zhì)免疫沉淀(ChIP-seq)和流式細(xì)胞分析,證明TET2通過(guò)調(diào)控DNA羥甲基化維持造血干細(xì)胞功能,缺失導(dǎo)致分化異常和白血病易感性增加。

3. **《Protocol for TET2 antibody validation in epigenetic studies》**

- Authors: An J, et al.

- 摘要:系統(tǒng)比較了多種商品化TET2抗體的特異性,通過(guò)siRNA敲除和質(zhì)譜驗(yàn)證抗體可靠性,為表觀遺傳學(xué)研究提供標(biāo)準(zhǔn)化實(shí)驗(yàn)方案,強(qiáng)調(diào)抗體選擇對(duì)結(jié)果準(zhǔn)確性的影響。

4. **《TET2 loss leads to increased inflammation》**

- Authors: Cimmino L, et al.

- 摘要:通過(guò)免疫熒光和免疫印跡(使用TET2抗體)發(fā)現(xiàn),TET2缺失的小鼠模型中炎癥因子表達(dá)升高,揭示了TET2在抑制免疫過(guò)度激活中的新功能,與自身免疫疾病相關(guān)。

注:以上為領(lǐng)域內(nèi)典型研究方向示例,實(shí)際文獻(xiàn)檢索建議通過(guò)PubMed或Google Scholar以"TET2 antibody"+"應(yīng)用方向(如leukemia/immunity/ChIP-seq)"為關(guān)鍵詞獲取最新研究。

       

背景信息

The TET2 (Ten-Eleven Translocation 2) antibody is a crucial tool in epigenetic research, targeting the TET2 protein, a member of the TET enzyme family. TET2 catalyzes the oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA, a key step in active DNA demethylation. This process regulates gene expression, cellular differentiation, and genomic stability. TET2 mutations are frequently observed in hematologic malignancies, such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and lymphoma, linking its dysfunction to tumorigenesis and clonal hematopoiesis.

TET2 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect TET2 expression levels, localization, and post-translational modifications in tissues or cell lines. They help elucidate TET2's role in developmental biology, cancer, and immune regulation. Researchers also utilize these antibodies to study correlations between TET2 loss/mutation and disease progression or therapeutic resistance.

Commercial TET2 antibodies are typically raised against specific epitopes, such as the C-terminal catalytic domain, and validated using knockout controls to ensure specificity. Challenges include distinguishing TET2 isoforms and avoiding cross-reactivity with TET1/TET3. As interest grows in targeting TET2 for epigenetic therapies or biomarkers, reliable antibodies remain essential for mechanistic studies and clinical diagnostics.

       
關(guān)鍵字: TET2抗體;TET2;TET2 Antibody;

公司簡(jiǎn)介

生物技術(shù)有限公司
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

TET2抗體;TET2 Antibody—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
碧云天生物技術(shù)有限公司
2025-07-17
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-24
¥4800
科博瑞(武漢)生物科技有限公司
2025-04-15
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