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Mouse Monoclonal GATA3 Antibody,Mouse Monoclonal GATA3 Antibody
  • Mouse Monoclonal GATA3 Antibody,Mouse Monoclonal GATA3 Antibody
  • Mouse Monoclonal GATA3 Antibody,Mouse Monoclonal GATA3 Antibody
  • Mouse Monoclonal GATA3 Antibody,Mouse Monoclonal GATA3 Antibody

GATA3抗體;GATA3 Antibody—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-25
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Mouse Monoclonal GATA3 Antibody英文名稱:Mouse Monoclonal GATA3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1291 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: GATA3
2025-05-25 Mouse Monoclonal GATA3 Antibody Mouse Monoclonal GATA3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1291 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHDR; HDRS
Entrez GeneID2625
clone2E6H5
WB Predicted band size48kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human GATA3 (AA: 287-301)
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using GATA3 mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是關(guān)于GATA3抗體的3篇參考文獻(xiàn),包含文獻(xiàn)名稱、作者及簡要摘要內(nèi)容:

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1. **文獻(xiàn)名稱**:*GATA3: A multispecific but potentially useful marker in surgical pathology*

**作者**:Miettinen M, et al.

**摘要**:該研究評估了GATA3抗體在多種腫瘤中的表達(dá),發(fā)現(xiàn)其在乳腺癌(尤其是雌激素受體陽性型)和尿路上皮癌中具有高敏感性,但在其他腫瘤(如鱗狀細(xì)胞癌、淋巴瘤)中表達(dá)較低,提示其作為乳腺和泌尿系統(tǒng)腫瘤診斷標(biāo)記的潛力。

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2. **文獻(xiàn)名稱**:*Utility of GATA3 Immunohistochemistry in the Differential Diagnosis of Urothelial Carcinoma*

**作者**:Liu H, et al.

**摘要**:研究比較了GATA3與其他標(biāo)記物(如p63)在尿路上皮癌和前列腺癌中的表達(dá)差異,證實GATA3對尿路上皮癌具有高特異性(>90%),是區(qū)分尿路上皮癌與其他腺癌的有效工具。

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3. **文獻(xiàn)名稱**:*GATA3 expression in metastatic breast carcinoma*

**作者**:Yang R, et al.

**摘要**:探討了GATA3在轉(zhuǎn)移性乳腺癌中的表達(dá)穩(wěn)定性,發(fā)現(xiàn)其與原發(fā)腫瘤的一致性較高(約85%),支持其在轉(zhuǎn)移性乳腺癌診斷中的應(yīng)用價值,尤其在缺乏其他特異性標(biāo)記時。

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4. **文獻(xiàn)名稱**:*Comparison of GATA3 and GCDFP-15 Expression in Breast and Non-breast Tumors*

**作者**:Chu PG, et al.

**摘要**:比較了GATA3與GCDFP-15在乳腺癌和其他腫瘤中的表達(dá),顯示GATA3的敏感性顯著高于GCDFP-15(75% vs. 25%),尤其在三陰性乳腺癌中更具優(yōu)勢。

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以上文獻(xiàn)聚焦于GATA3抗體在腫瘤診斷中的特異性、敏感性及臨床應(yīng)用場景,涵蓋乳腺癌、尿路上皮癌及轉(zhuǎn)移性腫瘤的鑒別診斷。

       

背景信息

GATA3 antibody is a valuable tool in both research and diagnostic pathology for detecting the presence of GATA3 protein, a transcription factor critical in cellular differentiation and tissue development. GATA3 belongs to the GATA family of zinc-finger transcription factors, which bind to DNA sequences containing the "GATA" motif to regulate gene expression. It plays essential roles in the development of various tissues, including the mammary glands, kidneys, and immune system, particularly in T-cell differentiation and Th2 cell polarization.

In diagnostic contexts, GATA3 is widely used as an immunohistochemical marker. It is highly expressed in hormone receptor-positive breast carcinomas and urothelial carcinomas, aiding in distinguishing these tumors from morphological mimics. Its expression is also observed in benign tissues like skin adnexa and salivary glands, necessitating careful interpretation. Beyond oncology, GATA3 is studied in immune disorders due to its role in immune cell regulation, linking it to allergies, asthma, and autoimmune diseases.

Commercially available GATA3 antibodies target specific epitopes, enabling applications in techniques like IHC, Western blot, and flow cytometry. However, staining intensity and specificity may vary depending on fixation methods and antibody clones. Ongoing research continues to explore its prognostic implications and therapeutic potential, particularly in cancers where GATA3 expression correlates with tumor behavior or treatment response.

       
關(guān)鍵字: GATA3抗體;GATA3;GATA3 Antibody;

公司簡介

生物技術(shù)有限公司
成立日期 2024-07-02 (1年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:生物試劑
  • 公司地址:青浦
詢盤

GATA3抗體;GATA3 Antibody—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
碧云天生物技術(shù)有限公司
2025-05-28
¥4800
科博瑞(武漢)生物科技有限公司
2025-04-15
¥1600.00
VIP9年
北京索萊寶科技有限公司
2025-06-04
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