Mouse Monoclonal FSHR Antibody,Mouse Monoclonal FSHR Antibody

FSHR抗體;FSHR Antibody—艾普蒂

價(jià)格	詢價(jià)
包裝	20μl	50μl	100μl

最小起訂量	1μl
發(fā)貨地	上海
更新日期	2025-05-25

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產(chǎn)品詳情

中文名稱:Mouse Monoclonal FSHR Antibody	英文名稱:Mouse Monoclonal FSHR Antibody
品牌: 艾普蒂	產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1270 year. Avoid repeated freeze / thaw cycles.	產(chǎn)品類別: 抗體
重組: 否	應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat	宿主: Mouse
偶聯(lián)物: 無	靶點(diǎn): FSHR

驗(yàn)證與應(yīng)用

應(yīng)用及物種

WB	咨詢技術(shù)	Human,Mouse,Rat
IF	咨詢技術(shù)	Human,Mouse,Rat
IHC	咨詢技術(shù)	Human,Mouse,Rat
ICC	技術(shù)咨詢	Human,Mouse,Rat
FCM	1/200 - 1/400	Human,Mouse,Rat
Elisa	1/10000	Human,Mouse,Rat

產(chǎn)品詳情

Aliases	LGR1; ODG1; FSHR1; FSHRO
Entrez GeneID	2492
clone	3D5G9
WB Predicted band size	78.3kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human FSHR (AA: extra 18-366) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of Hela cells using FSHR mouse mAb (green) and negative control (red).

參考文獻(xiàn)

以下是關(guān)于FSHR抗體的3篇代表性文獻(xiàn)摘要(信息基于公開研究整理，非實(shí)時(shí)最新數(shù)據(jù))：

1. **文獻(xiàn)名稱**：《Monoclonal Antibodies Targeting Follicle-Stimulating Hormone Receptor for Ovarian Cancer Therapy》

**作者**：Li Y, et al.

**摘要**：研究開發(fā)了一種靶向FSHR的單克隆抗體，證實(shí)其在卵巢癌細(xì)胞中特異性結(jié)合并抑制腫瘤生長?？贵w通過阻斷FSH信號(hào)通路，誘導(dǎo)細(xì)胞凋亡，并在小鼠模型中顯著減少腫瘤體積，提示其作為卵巢癌靶向治療的潛力。

2. **文獻(xiàn)名稱**：《Autoantibodies Against Follicle-Stimulating Hormone Receptor in Infertility》

**作者**：Jiang X, et al.

**摘要**：探討了FSHR自身抗體與女性不明原因不孕癥的關(guān)系。研究發(fā)現(xiàn)部分患者血清中存在FSHR抗體，這些抗體干擾FSH與受體結(jié)合，導(dǎo)致卵巢反應(yīng)低下和排卵障礙，提示抗體檢測或成為輔助生殖治療的分層指標(biāo)。

3. **文獻(xiàn)名稱**：《FSHR Antibody Engineering for Enhanced Targeting in Reproductive Disorders》

**作者**：Smith A, et al.

**摘要**：通過抗體工程技術(shù)改造FSHR抗體的親和力與特異性，開發(fā)出可逆性阻斷FSHR的雙功能抗體。該抗體在靈長類動(dòng)物模型中成功調(diào)節(jié)卵泡發(fā)育，為多囊卵巢綜合征等生殖內(nèi)分泌疾病提供潛在治療策略。

(注：以上文獻(xiàn)為模擬示例，實(shí)際引用請(qǐng)通過PubMed或?qū)W術(shù)數(shù)據(jù)庫檢索最新研究。)

背景信息

Follicle-stimulating hormone receptor (FSHR) antibodies are biomolecules targeting FSHR, a G protein-coupled receptor critical in reproductive physiology. Expressed primarily in ovarian granulosa cells and testicular Sertoli cells, FSHR regulates folliculogenesis in females and spermatogenesis in males. Anti-FSHR antibodies can be either agonistic or antagonistic, modulating receptor activity. Naturally occurring autoantibodies against FSHR are rare but linked to infertility, ovarian resistance syndromes, or autoimmune disorders.

Research focuses on engineered FSHR antibodies for therapeutic applications. Monoclonal antibodies (mAbs) blocking FSHR signaling are explored in contraception and oncology, particularly cancers expressing FSHR (e.g., ovarian, prostate). Conversely, agonistic antibodies mimicking FSH action may assist in vitro fertilization by enhancing follicular development. Challenges include ensuring antibody specificity due to FSHR's structural homology with other glycoprotein hormone receptors. Recent advances utilize recombinant FSHR extracellular domains or cell-based immunization to generate high-affinity antibodies. Clinical trials remain limited, but preclinical studies highlight their potential in targeting FSHR-overexpressing tumors while sparing normal tissues. Ethical and safety concerns persist, particularly regarding off-target effects on reproductive tissues. Ongoing studies aim to optimize antibody design for precision therapeutics in reproductive health and oncology.

關(guān)鍵字： FSHR抗體;FSHR;FSHR Antibody;

公司簡介

生物技術(shù)有限公司

成立日期	2024-07-02 （2年）	注冊(cè)資本	20萬人民幣
員工人數(shù)	1-10人	年?duì)I業(yè)額	￥ 100萬以內(nèi)
主營行業(yè)	抗體,植物生物技術(shù),細(xì)胞培養(yǎng),蛋白組學(xué)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

上海切爾齊生物科技有限公司

VIP 1年

公司成立：2年
注冊(cè)資本：20萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：生物試劑
公司地址：青浦

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