The SGPL1 (sphingosine-1-phosphate lyase 1) antibody is a tool used to study the enzyme encoded by the *SGPL1* gene, which plays a critical role in sphingolipid metabolism. SGPL1 catalyzes the irreversible cleavage of sphingosine-1-phosphate (S1P), a bioactive lipid involved in cellular processes like proliferation, apoptosis, and immune regulation. Dysregulation of SGPL1 is linked to diseases such as steroid-resistant nephrotic syndrome, primary adrenal insufficiency, and neurological disorders. The antibody detects SGPL1 protein expression in various tissues, aiding research into its function and distribution. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore SGPL1's role in health and disease. Studies also utilize the antibody to investigate therapeutic strategies targeting the S1P pathway in cancer, autoimmune conditions, and metabolic disorders.