The PKD2 antibody is a crucial tool for studying polycystin-2. a protein encoded by the *PKD2* gene. Polycystin-2. also known as TRPP2. is a member of the transient receptor potential (TRP) channel family and functions as a calcium-permeable cation channel. It plays a vital role in regulating intracellular calcium signaling, cell proliferation, and fluid secretion. Mutations in *PKD2* are linked to autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder characterized by renal cyst formation, hypertension, and progressive kidney failure.
PKD2 antibodies are widely used in research to detect and quantify polycystin-2 expression in tissues or cell lines, aiding in the investigation of its localization, interaction partners, and functional mechanisms. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Additionally, they help elucidate the molecular pathogenesis of ADPKD by identifying aberrant polycystin-2 expression or trafficking in disease models.
Commercial PKD2 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and their specificity is validated using knockout controls. Researchers rely on these antibodies to explore therapeutic strategies targeting polycystin-2 dysfunction, including calcium signaling modulation or cyst growth inhibition. Overall, PKD2 antibodies are indispensable for advancing our understanding of polycystin-2 biology and its role in cystic diseases.