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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P09770(CLIP3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

The CLIP3 antibody targets the CLIP3 protein (Cytoplasmic Linker Protein 3), also known as RSNL2 or CLIP-170-related protein, which plays a role in intracellular trafficking, membrane dynamics, and cytoskeletal organization. CLIP3 belongs to the CLIP family of proteins that interact with microtubules and regulate vesicle transport, cell polarization, and signal transduction. It contains a conserved N-terminal CAP-Gly domain for microtubule binding and a C-terminal region mediating interactions with other proteins or membranes.

CLIP3 is implicated in diverse cellular processes, including endocytosis, receptor recycling, and Wnt/β-catenin signaling. Studies suggest its involvement in cancer progression, where it may influence cell migration, invasion, and metastasis. For instance, CLIP3 overexpression has been linked to enhanced EGFR trafficking in glioblastoma and colorectal cancer. Its antibody is widely used in research to investigate these mechanisms via techniques like immunofluorescence, Western blotting, and co-immunoprecipitation.

The development of CLIP3 antibodies has advanced studies on its role in pathological conditions, particularly oncology and neurobiology. Researchers utilize these tools to explore CLIP3's potential as a biomarker or therapeutic target, given its regulatory effects on critical pathways. However, its functional diversity across tissues and contexts necessitates further investigation to clarify its precise molecular roles and clinical relevance.