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GDI2抗體,Rabbit Polyclonal GDI2 Antibody
  • GDI2抗體,Rabbit Polyclonal GDI2 Antibody
  • GDI2抗體,Rabbit Polyclonal GDI2 Antibody
  • GDI2抗體,Rabbit Polyclonal GDI2 Antibody

GDI2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GDI2抗體英文名稱:Rabbit Polyclonal GDI2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 5023 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: GDI2
2025-05-14 GDI2抗體 Rabbit Polyclonal GDI2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 5023 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesRABGDIB; HEL-S-46e
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human GDI2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HT-29 and Jurkat cell lysates, Primary antibody: P09721(GDI2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09721(GDI2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于GDI2抗體的參考文獻(xiàn)示例(內(nèi)容為模擬生成,實際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫驗證):

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1. **標(biāo)題**: *GDI2 regulates exocytosis and invasion in breast cancer cells*

**作者**: Smith A, et al.

**摘要**: 研究揭示了GDI2通過調(diào)控Rab蛋白活性影響乳腺癌細(xì)胞囊泡運輸,促進(jìn)腫瘤侵襲。研究采用GDI2抗體進(jìn)行Western blot和免疫熒光,證實其高表達(dá)與患者不良預(yù)后相關(guān)。

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2. **標(biāo)題**: *Characterization of a novel monoclonal antibody against GDI2 for neurodegenerative studies*

**作者**: Lee H, et al.

**摘要**: 報道了一種特異性識別GDI2的單克隆抗體的開發(fā)與驗證,該抗體成功用于小鼠腦組織的免疫組化分析,表明GDI2在神經(jīng)元突觸功能中的潛在作用。

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3. **標(biāo)題**: *GDI2 as a biomarker in pancreatic cancer: Role in chemoresistance*

**作者**: Chen R, et al.

**摘要**: 通過免疫沉淀(使用GDI2抗體)發(fā)現(xiàn),GDI2過表達(dá)通過穩(wěn)定Rab27a增強(qiáng)胰腺癌細(xì)胞外泌體分泌,導(dǎo)致化療藥物外排和耐藥性。

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4. **標(biāo)題**: *Functional interplay between GDI1 and GDI2 in membrane trafficking*

**作者**: Martinez O, et al.

**摘要**: 對比GDI1/GDI2抗體實驗,發(fā)現(xiàn)兩者在調(diào)控不同Rab蛋白循環(huán)中的互補(bǔ)作用,GDI2更傾向于參與分泌途徑,影響細(xì)胞膜修復(fù)過程。

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建議通過PubMed或Google Scholar以“GDI2 antibody”或“GDI2 function”為關(guān)鍵詞檢索最新文獻(xiàn),并核實實驗細(xì)節(jié)。

       

背景信息

**Background of GDI2 Antibody**

GDI2 (GDP dissociation inhibitor 2) is a member of the Rab GDP dissociation inhibitor (GDI) family, which regulates the activity of small GTPases, particularly Rab proteins involved in intracellular vesicle trafficking and membrane dynamics. GDI2 binds to Rab proteins in their inactive GDP-bound state, sequestering them in the cytoplasm and preventing premature membrane association. This regulatory mechanism is critical for maintaining cellular processes such as exocytosis, endocytosis, and organelle biogenesis.

The GDI2 antibody is a tool developed to detect and study the expression, localization, and function of GDI2 in various biological contexts. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate GDI2's role in health and disease. Studies have linked GDI2 dysregulation to pathologies, including cancer and neurodegenerative disorders. For example, altered GDI2 expression has been observed in certain tumors, suggesting potential implications in cancer progression or metastasis.

Research utilizing GDI2 antibodies also explores its interplay with other trafficking regulators, such as GDI1. and its tissue-specific roles. Compared to GDI1. GDI2 exhibits distinct expression patterns and functional redundancies, highlighting the need for specific reagents like GDI2 antibodies to dissect their unique contributions. Overall, GDI2 antibodies serve as essential tools for unraveling the molecular mechanisms of vesicle trafficking and their relevance to human diseases.

       
關(guān)鍵字: GDI2抗體;GDI2;GDI2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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