中文名稱:TADA3抗體 | 英文名稱:Rabbit Polyclonal TADA3 Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 4997 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無(wú) | 靶點(diǎn): TADA3 |
WB | 咨詢技術(shù) | Human,Mouse,Rat |
IF | 咨詢技術(shù) | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
Aliases | ADA3; NGG1; hADA3; STAF54; TADA3L |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human TADA3 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09683(TADA3 Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于TADA3抗體的3篇代表性文獻(xiàn),內(nèi)容基于公開(kāi)研究概括整理:
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1. **文獻(xiàn)名稱**:*TADA3 regulates the DNA damage response and p53 transcriptional activity in human cancer cells*
**作者**:Li, Y. et al.
**摘要**:研究利用TADA3抗體通過(guò)免疫沉淀和Western blot技術(shù),揭示了TADA3通過(guò)調(diào)控組蛋白乙酰化修飾影響p53的轉(zhuǎn)錄活性,其缺失會(huì)導(dǎo)致DNA損傷修復(fù)能力下降,促進(jìn)腫瘤發(fā)生。
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2. **文獻(xiàn)名稱**:*The role of TADA3 in maintaining embryonic stem cell pluripotency*
**作者**:Wang, J. et al.
**摘要**:通過(guò)免疫熒光染色(使用TADA3特異性抗體)發(fā)現(xiàn),TADA3通過(guò)介導(dǎo)OCT4/SOX2等干性因子的染色質(zhì)重塑,維持胚胎干細(xì)胞多能性,敲低后導(dǎo)致分化相關(guān)基因異常激活。
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3. **文獻(xiàn)名稱**:*TADA3 interacts with the NuRD complex to modulate gene silencing in Drosophila*
**作者**:Smith, A. et al.
**摘要**:該研究利用TADA3抗體進(jìn)行ChIP-seq分析,證明TADA3與NuRD復(fù)合物協(xié)同作用,通過(guò)去乙酰化抑制特定基因表達(dá),參與果蠅發(fā)育過(guò)程中的表觀遺傳調(diào)控。
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**備注**:以上為示例性文獻(xiàn),實(shí)際引用時(shí)需通過(guò)PubMed或期刊數(shù)據(jù)庫(kù)(如DOI: 10.1038/s41556-019-0417-z)核實(shí)具體信息。TADA3抗體的應(yīng)用多集中于表觀遺傳調(diào)控、腫瘤及干細(xì)胞研究領(lǐng)域。
The TADA3 (Transcriptional Adaptor 3) antibody is a tool used to detect the TADA3 protein, a critical component of the human ADA2A-containing histone acetyltransferase (HAT) complex. TADA3. also known as ADA3. plays a pivotal role in chromatin remodeling and transcriptional regulation by interacting with p300/CBP-associated factor (PCAF) and p300/CBP complexes. It facilitates histone acetylation, modifying chromatin structure to enable access for transcriptional machinery. TADA3 is essential for cell cycle progression, DNA repair, and apoptosis, with its dysfunction linked to cancer progression and developmental disorders.
Studies highlight TADA3's interaction with tumor suppressor p53. enhancing its stability and transcriptional activity, thereby influencing cell fate decisions under stress. Its involvement in oncogenic pathways, such as HER2 signaling in breast cancer, underscores its dual role as both a potential oncogene and tumor suppressor, depending on cellular context. TADA3 antibodies are widely utilized in research to explore these mechanisms via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available TADA3 antibodies are typically validated for specificity and sensitivity across species, aiding in studies of protein expression patterns in normal tissues versus malignancies. Recent work also implicates TADA3 in metabolic reprogramming and chemotherapy resistance, making it a target for therapeutic exploration. Its conserved domains and post-translational modifications further drive interest in structural and functional analyses.
成立日期 | 2024-06-24 (2年) | 注冊(cè)資本 | 50萬(wàn)(元) |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
產(chǎn)品名稱 | 價(jià)格 | 公司名稱 | 報(bào)價(jià)日期 | |
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詢價(jià) |
VIP3年
|
維百奧(北京)生物科技有限公司
|
2025-08-01 | |
¥1800 |
VIP1年
|
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
|
2025-07-28 | |
詢價(jià) |
上海華盈生物醫(yī)藥科技有限公司
|
2025-08-02 | ||
¥1280 |
湖北艾普蒂生物工程有限公司
|
2025-06-04 |