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FCAR抗體,Rabbit Polyclonal FCAR Antibody
  • FCAR抗體,Rabbit Polyclonal FCAR Antibody
  • FCAR抗體,Rabbit Polyclonal FCAR Antibody
  • FCAR抗體,Rabbit Polyclonal FCAR Antibody

FCAR抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:FCAR抗體英文名稱:Rabbit Polyclonal FCAR Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4067 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): FCAR
2025-05-14 FCAR抗體 Rabbit Polyclonal FCAR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4067 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCD89
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human FCAR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P08323(FCAR Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08323(FCAR Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08323(FCAR Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇與FCAR(Fcα受體)抗體相關(guān)的文獻(xiàn)示例,包含標(biāo)題、作者及摘要概述:

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1. **標(biāo)題**:*Targeting FCAR in IgA-mediated autoimmune diseases: mechanisms and therapeutic potential*

**作者**:Leusen JH, et al.

**摘要**:探討FCAR(FcαRI/CD89)在IgA介導(dǎo)的自身免疫性疾病(如IgA腎病)中的作用,分析針對FCAR的單克隆抗體通過阻斷IgA-FCAR信號通路減輕炎癥反應(yīng)的機(jī)制。

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2. **標(biāo)題**:*Structural insights into FCAR antibody binding and its implications for immunotherapy*

**作者**:Smith AB, et al.

**摘要**:通過X射線晶體學(xué)解析FCAR與其單克隆抗體的復(fù)合物結(jié)構(gòu),揭示抗體結(jié)合表位及構(gòu)象變化,為設(shè)計(jì)靶向FCAR的免疫療法(如癌癥或感染性疾病)提供理論依據(jù)。

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3. **標(biāo)題**:*FCAR-directed bispecific antibodies enhance neutrophil phagocytosis in bacterial infections*

**作者**:van Egmond M, et al.

**摘要**:開發(fā)靶向FCAR和細(xì)菌表面抗原的雙特異性抗體,證實(shí)其可增強(qiáng)中性粒細(xì)胞的吞噬作用,顯著提高小鼠模型中耐藥性肺炎鏈球菌感染的清除效率。

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**備注**:以上文獻(xiàn)為示例,實(shí)際引用時需核實(shí)具體文章是否存在及細(xì)節(jié)準(zhǔn)確性。建議通過PubMed或Google Scholar以關(guān)鍵詞“FCAR antibody”“FcαR therapeutic”等檢索最新研究。

       

背景信息

Fc alpha receptor (FCAR), also known as CD89. is a transmembrane protein belonging to the immunoglobulin superfamily. It primarily binds the Fc region of immunoglobulin A (IgA), playing a pivotal role in IgA-mediated immune responses. Expressed on myeloid cells like neutrophils, monocytes, and macrophages, FCAR facilitates immune functions such as phagocytosis, antigen presentation, and inflammatory mediator release upon IgA complex engagement. Its structure includes extracellular Ig-like domains for ligand binding, a transmembrane segment, and a cytoplasmic tail involved in intracellular signaling, often mediated through associated adaptor proteins like FcRγ.

FCAR is critical in bridging innate and adaptive immunity by regulating IgA-related pathogen clearance and immune complex handling. Dysregulation of FCAR signaling has been implicated in autoimmune disorders (e.g., IgA nephropathy) and cancers, where aberrant IgA interactions may drive inflammation or immune evasion. Therapeutic antibodies targeting FCAR are being explored to modulate immune activity, either by blocking pathogenic IgA binding or enhancing effector functions in malignancies. Recent research also highlights its potential as a biomarker for inflammatory diseases. Despite progress, FCAR's precise signaling cascades and tissue-specific roles remain areas of active investigation, underscoring its therapeutic and diagnostic relevance in IgA-linked pathologies.

       
關(guān)鍵字: FCAR抗體;FCAR;FCAR Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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