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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P08180(CRELD2 Antibody) at dilution 1/421, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P08180(CRELD2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08180(CRELD2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The CRELD2 (Cysteine-Rich with EGF-Like Domains 2) antibody is a tool used to study the CRELD2 protein, a member of the CRELD family implicated in cellular processes such as protein folding, endoplasmic reticulum (ER) stress response, and cell adhesion. CRELD2 is structurally characterized by multiple cysteine-rich motifs and epidermal growth factor (EGF)-like domains, which are thought to mediate protein-protein interactions. While its exact biological role remains under investigation, CRELD2 has been linked to ER quality control pathways, potentially assisting in the maturation or degradation of misfolded proteins. Dysregulation of CRELD2 has been associated with diseases, including certain cancers and congenital disorders, highlighting its potential clinical relevance.

Antibodies targeting CRELD2 are typically generated using immunogens derived from recombinant protein fragments or synthetic peptides corresponding to specific regions of the human or murine CRELD2 sequence. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Researchers use CRELD2 antibodies to explore its expression patterns, subcellular localization (e.g., ER residency), and interactions with chaperones like calnexin or BiP during stress conditions. Recent studies also investigate its role in tumor progression, where elevated CRELD2 levels may correlate with metastasis or drug resistance. Robust validation, including knockout cell line controls, is critical to ensure specificity due to potential cross-reactivity with other cysteine-rich proteins.